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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2008-1-16
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pubmed:abstractText |
Rac small GTPases may play an important regulatory role in osteoclastogenesis. Our in vitro and in vivo results show that both Rac1 and Rac2 are required for optimal osteoclast differentiation, but Rac1 is more critical. Rac1 is the key Rac isoform responsible for regulating ROS generation and the actin cytoskeleton during the multiple stages of osteoclast differentiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acid Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsin K,
http://linkedlifedata.com/resource/pubmed/chemical/Cathepsins,
http://linkedlifedata.com/resource/pubmed/chemical/Ctsk protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Neuropeptides,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Rac1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Reactive Oxygen Species,
http://linkedlifedata.com/resource/pubmed/chemical/rac GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/rac2 GTP-binding protein,
http://linkedlifedata.com/resource/pubmed/chemical/tartrate-resistant acid phosphatase
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1523-4681
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
260-70
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17922611-Acid Phosphatase,
pubmed-meshheading:17922611-Animals,
pubmed-meshheading:17922611-Cathepsin K,
pubmed-meshheading:17922611-Cathepsins,
pubmed-meshheading:17922611-Cell Differentiation,
pubmed-meshheading:17922611-Gene Deletion,
pubmed-meshheading:17922611-Isoenzymes,
pubmed-meshheading:17922611-Mice,
pubmed-meshheading:17922611-Mice, Knockout,
pubmed-meshheading:17922611-Mice, Transgenic,
pubmed-meshheading:17922611-Models, Biological,
pubmed-meshheading:17922611-Monocytes,
pubmed-meshheading:17922611-Neuropeptides,
pubmed-meshheading:17922611-Osteoclasts,
pubmed-meshheading:17922611-Protein Isoforms,
pubmed-meshheading:17922611-RNA, Messenger,
pubmed-meshheading:17922611-Reactive Oxygen Species,
pubmed-meshheading:17922611-rac GTP-Binding Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
Identifying the relative contributions of Rac1 and Rac2 to osteoclastogenesis.
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pubmed:affiliation |
CIHR Group in Matrix Dynamics, University of Toronto, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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