Although identification of the primary tumor in patients with metastatic adenocarcinoma has a profound clinical impact, diagnosing the organ of origin is frequently difficult. Because none of the individual immunohistochemical markers used for tissue identification are both site specific and site sensitive, multiple markers are needed to improve the prediction of primary sites.
Department of Pathology, Seoul National University College of Medicine and Cancer Research Institute, 28 Yongon-dong, Chongno-gu, Seoul 110-744, South Korea.
