Source:http://linkedlifedata.com/resource/pubmed/id/17922027
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
14
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pubmed:dateCreated |
2008-3-27
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pubmed:abstractText |
ATP-dependent SWI/SNF chromatin remodeling complexes regulate cell-cycle and play critical roles in a variety of differentiation pathways. The core subunit SNF5/INI1 is a tumor suppressor that is inactivated in a highly aggressive childhood cancer of unknown cellular origin, termed malignant rhabdoid tumor (MRT). The highly undifferentiated phenotype of this tumor suggests that the loss-of-function of hSNF5/INI1 impairs specific differentiation programs of the MRT parental cell. Based on the hypothesis that these programs might be reinitialized upon hSNF5/INI1 re-expression in MRTs, we show that some MRT cell lines can differentiate toward the adipogenic lineage. We further show that the knock down of the SNF5/INI1 subunit abrogates adipocyte differentiation of murine 3T3-L1 preadipocytes and of human mesenchymal stem cells. Finally, we provide evidence that hSNF5/INI1 cooperates with C/EBPbeta and PPARgamma2 transcriptional regulators to activate the expression of adipocyte-specific genes. These data indicate that not only the ATPase subunit of the SWI/SNF complex, but also SNF5/INI1 is required for adipocyte differentiation. They further show that MRT cell lines harbor an adipogenic differentiation potential and that the tumor suppressor role of the SNF5/INI1 subunit may rely on its ability to regulate the balance between cell proliferation and differentiation.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCAAT-Enhancer-Binding Protein-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Chromosomal Proteins, Non-Histone,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Suppressor Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
1476-5594
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2035-44
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pubmed:meshHeading |
pubmed-meshheading:17922027-3T3-L1 Cells,
pubmed-meshheading:17922027-Adipocytes,
pubmed-meshheading:17922027-Adipogenesis,
pubmed-meshheading:17922027-Animals,
pubmed-meshheading:17922027-CCAAT-Enhancer-Binding Protein-beta,
pubmed-meshheading:17922027-Cell Line, Tumor,
pubmed-meshheading:17922027-Cell Proliferation,
pubmed-meshheading:17922027-Chromatin Assembly and Disassembly,
pubmed-meshheading:17922027-Chromosomal Proteins, Non-Histone,
pubmed-meshheading:17922027-DNA-Binding Proteins,
pubmed-meshheading:17922027-Humans,
pubmed-meshheading:17922027-Mice,
pubmed-meshheading:17922027-PPAR gamma,
pubmed-meshheading:17922027-Rhabdoid Tumor,
pubmed-meshheading:17922027-Transcription Factors,
pubmed-meshheading:17922027-Tumor Suppressor Proteins
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pubmed:year |
2008
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pubmed:articleTitle |
The requirement for SNF5/INI1 in adipocyte differentiation highlights new features of malignant rhabdoid tumors.
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pubmed:affiliation |
Institut Curie, Research Section, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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