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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
1992-4-2
|
| pubmed:abstractText |
The connective matrix participates directly in early pathological events observed in the cutaneous lesion of leishmaniasis, due to Leishmania braziliensis guyanensis. A sample of 19 skin biopsies was examined by light and electron microscopy, in order to identify the matrix components (collagen isotypes I to IV, elastin and membrane associated proteins) of the dermal infiltrate, and the pattern of organization of the reparative connective matrix. An extensive remodelling process of apparently parasite-independent nature involves different fibroblast sub-populations. The original organization of this immune-mediated lesion offers a rare opportunity to study in situ the local inflammatory mediators inducing the activation of fibroblasts and macrophages.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0344-0338
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
187
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
924-30
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1792187-Adolescent,
pubmed-meshheading:1792187-Adult,
pubmed-meshheading:1792187-Animals,
pubmed-meshheading:1792187-Biopsy,
pubmed-meshheading:1792187-Collagen,
pubmed-meshheading:1792187-Connective Tissue,
pubmed-meshheading:1792187-Elastin,
pubmed-meshheading:1792187-Extracellular Matrix,
pubmed-meshheading:1792187-Fibroblasts,
pubmed-meshheading:1792187-Fluorescent Antibody Technique,
pubmed-meshheading:1792187-Granuloma,
pubmed-meshheading:1792187-Host-Parasite Interactions,
pubmed-meshheading:1792187-Humans,
pubmed-meshheading:1792187-Leishmaniasis, Cutaneous,
pubmed-meshheading:1792187-Male,
pubmed-meshheading:1792187-Membrane Proteins,
pubmed-meshheading:1792187-Microscopy, Electron,
pubmed-meshheading:1792187-Phenotype
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Matrix remodelling and fibroblast phenotype in early lesions of human cutaneous leishmaniasis.
|
| pubmed:affiliation |
Parasitology Laboratory, Institut Pasteur de Guyane française, Cayenne, French Guiana.
|
| pubmed:publicationType |
Journal Article
|