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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
48
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pubmed:dateCreated |
2007-11-26
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pubmed:abstractText |
Several protein-tyrosine phosphatases (PTPs) have been implicated in the control of growth hormone receptor (GHR) signaling, but none have been shown to affect growth in vivo. We have applied a battery of molecular and cellular approaches to test a family-wide panel of PTPs for interference with GHR signaling. Among the subset of PTPs that showed activity in multiple readouts, we selected PTP-H1/PTPN3 for further in vivo studies and found that mice lacking the PTP-H1 catalytic domain show significantly enhanced growth over their wild type littermates. In addition, PTP-H1 mutant animals had enhanced plasma and liver mRNA expression of insulin-like growth factor 1, as well as increased bone density and mineral content. These observations point to a controlling role for PTP-H1 in modulating GHR signaling and systemic growth through insulin-like growth factor 1 secretion.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0021-9258
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pubmed:author |
pubmed-author:ClarkAnnA,
pubmed-author:CurchodMarie-LaureML,
pubmed-author:Hooft van HuijsduijnenRobR,
pubmed-author:MagnoneMaria ChiaraMC,
pubmed-author:PatrignaniClaudiaC,
pubmed-author:PerrinDominiqueD,
pubmed-author:PesciniRosannaR,
pubmed-author:PileckaIwonaI,
pubmed-author:RommelChristianC,
pubmed-author:ValenzuelaDavidD,
pubmed-author:XueYingziY,
pubmed-author:YasenchakJasonJ,
pubmed-author:ZaratinPaolaP
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
282
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
35405-15
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pubmed:dateRevised |
2009-11-3
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pubmed:meshHeading |
pubmed-meshheading:17921143-Animals,
pubmed-meshheading:17921143-Catalytic Domain,
pubmed-meshheading:17921143-Cell Proliferation,
pubmed-meshheading:17921143-Female,
pubmed-meshheading:17921143-Humans,
pubmed-meshheading:17921143-Insulin-Like Growth Factor I,
pubmed-meshheading:17921143-Liver,
pubmed-meshheading:17921143-Male,
pubmed-meshheading:17921143-Mice,
pubmed-meshheading:17921143-Mice, Knockout,
pubmed-meshheading:17921143-Models, Biological,
pubmed-meshheading:17921143-Mutation,
pubmed-meshheading:17921143-Phosphorylation,
pubmed-meshheading:17921143-Protein Tyrosine Phosphatase, Non-Receptor Type 3,
pubmed-meshheading:17921143-RNA, Messenger,
pubmed-meshheading:17921143-Receptors, Somatotropin,
pubmed-meshheading:17921143-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
Protein-tyrosine phosphatase H1 controls growth hormone receptor signaling and systemic growth.
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pubmed:affiliation |
Merck Serono International, 1211 Geneva, Switzerland.
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pubmed:publicationType |
Journal Article
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