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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
22
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pubmed:dateCreated |
2007-10-25
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pubmed:abstractText |
Two new C-1 epimeric hydroxymethyl castanospermine congeners 2a and 2b, synthesized by stereocontrolled intramolecular double reductive amination of D-glucose derived beta-keto ester as a key step, showed impressive immuno-potentiating property. The bioactivity was mediated through up-regulation of T(H1)/T(H2) cytokine ratio. The finding suggested that immunmodulatory activity of polyhydroxylated indolizidine alkaloids can be tuned by minor structural/stereochemical alterations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5519-23
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pubmed:meshHeading |
pubmed-meshheading:17918922-Adjuvants, Immunologic,
pubmed-meshheading:17918922-Animals,
pubmed-meshheading:17918922-Cell Proliferation,
pubmed-meshheading:17918922-Concanavalin A,
pubmed-meshheading:17918922-Cytokines,
pubmed-meshheading:17918922-Drug Synergism,
pubmed-meshheading:17918922-Indolizines,
pubmed-meshheading:17918922-Mice,
pubmed-meshheading:17918922-Spleen,
pubmed-meshheading:17918922-Stereoisomerism,
pubmed-meshheading:17918922-Th1 Cells,
pubmed-meshheading:17918922-Th2 Cells
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of 1-deoxy-1-hydroxymethyl- and 1-deoxy-1-epi-hydroxymethyl castanospermine as new potential immunomodulating agents.
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pubmed:affiliation |
Garware Research Centre, Department of Chemistry, University of Pune, Pune-411 007, India.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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