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rdf:type |
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lifeskim:mentions |
umls-concept:C0008633,
umls-concept:C0015576,
umls-concept:C0017258,
umls-concept:C0023745,
umls-concept:C0175630,
umls-concept:C0260832,
umls-concept:C0441889,
umls-concept:C0489835,
umls-concept:C1332927,
umls-concept:C1337092,
umls-concept:C1522558,
umls-concept:C1705079,
umls-concept:C1955970
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pubmed:issue |
8
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pubmed:dateCreated |
2007-12-6
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pubmed:abstractText |
Atherogenesis is a chronic inflammatory process. Critical in the inflammation process is monocyte chemoattractant protein-1 (MCP-1). To locate genomic regions that affect circulating MCP-1 levels, a genome-wide linkage scan was conducted in a sample of whites and blacks. Phenotype and genetic marker data were available for 2501 white and 513 black participants in the National Heart Lung Blood Institute Family Heart Study follow-up examination. Heritability for MCP-1 was 0.37 in whites and 0.47 in blacks after adjusting for the effects of sex, age, age-sex interaction, smoking status, lifetime smoking exposure (pack-years) and field center. Significant linkage was observed for MCP-1 in a combined black and white sample on chromosome 3 (logarithm of the odds ratio (LOD)=3.5 at 78 cM, P=0.0001) and suggestive linkage was observed in whites on chromosome 5 (LOD=1.8 at 128 cM, P=0.002). Located under the linkage peak on chromosome 3 is the chemokine receptor gene cluster, including CCR2, the receptor for MCP-1. This study provides preliminary evidence linking genetic variation in a receptor to circulating levels of its ligand, as previously demonstrated for the low-density lipoprotein receptor. Further characterization of these chromosomal regions is needed to identify the functional mutations associated with circulating levels of MCP-1.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/T32 HL007972,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56563,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56564,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56565,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56566,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56567,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56568,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL56569,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67893,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67894,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67895,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67896,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67897,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67898,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67899,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67900,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67901,
http://linkedlifedata.com/resource/pubmed/grant/U01 HL67902
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1466-4879
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
684-90
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17917677-Adult,
pubmed-meshheading:17917677-African Continental Ancestry Group,
pubmed-meshheading:17917677-Aged,
pubmed-meshheading:17917677-Aged, 80 and over,
pubmed-meshheading:17917677-Atherosclerosis,
pubmed-meshheading:17917677-Chemokine CCL2,
pubmed-meshheading:17917677-Chromosomes, Human, Pair 3,
pubmed-meshheading:17917677-European Continental Ancestry Group,
pubmed-meshheading:17917677-Female,
pubmed-meshheading:17917677-Genetic Linkage,
pubmed-meshheading:17917677-Humans,
pubmed-meshheading:17917677-Male,
pubmed-meshheading:17917677-Middle Aged,
pubmed-meshheading:17917677-Multigene Family,
pubmed-meshheading:17917677-National Heart, Lung, and Blood Institute (U.S.),
pubmed-meshheading:17917677-Receptors, Chemokine,
pubmed-meshheading:17917677-United States
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pubmed:year |
2007
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pubmed:articleTitle |
Circulating MCP-1 levels shows linkage to chemokine receptor gene cluster on chromosome 3: the NHLBI family heart study follow-up examination.
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pubmed:affiliation |
Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN 55454, USA. bielinski@epi.umm.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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