Linked Life Data

17917163

Source:http://linkedlifedata.com/resource/pubmed/id/17917163

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2007-10-5
pubmed:abstractText
Mitochondria play a pivotal role in the life and death of cells and likely contribute importantly to the initiation or progression of many neurodegenerative disorders. Brain is especially vulnerable to lipid peroxidation because of its enrichment in polyunsaturated fatty acids relative to other organs. Multiple studies demonstrate the elevation of numerous lipid peroxidation products and ensuing lipid-derived carbonyls in Alzheimer's disease. In this review, we examine the data describing the effects of lipid-derived carbonyls such as 4-hydroxy-trans-2-nonenal (HNE) and acrolein upon the function of brain mitochondria as well as review the detoxification routes of these carbonyls. From these data, we show that the physical-chemical properties of these carbonyls influence their effects on mitochondria and that multiple essential mitochondrial functions are altered by these endogenous reactive carbonyls. Lastly, we examine the role of mitochondrial aldehyde detoxification pathways and their potential role in the development of AD.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1387-2877
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
185-93
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Mitochondrial effects of lipid-derived neurotoxins.
pubmed:affiliation
Department of Pharmacology, Physiology, and Therapeutics, University of North Dakota School of Medicine, Grand Forks, ND 58203, USA. mpicklo@medicine.nodak.edu
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural