Linked Life Data

17917040

Source:http://linkedlifedata.com/resource/pubmed/id/17917040

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-3
pubmed:dateCreated
2007-10-5
pubmed:abstractText
Infection of mice with Listeria monocytogenes has led to a puzzling observation: mice deficient in lymphocytes are more resistant during the early innate immune response. This is counterintuitive, because mice deficient in the adaptive immune response are unable to clear the infection and eventually die. This work will highlight some of our recent work on Listeria induced apoptosis and its immunological consequences. We show that Listeria produces a toxin, listeriolysin O (LLO), which causes apoptosis of lymphocytes in vitro and in vivo. Early during the infection, type I interferon sensitizes lymphocytes to die by LLO-induced apoptosis. The cell death peaks during the first two days of the infection, leading to the production of IL-10 and downregulation of anti-microbial activity in the spleen. The induction of apoptosis by Listeria creates an infective niche in the peri-arteriolar lymphoid sheaths of the spleen which allows the bacteria to grow exponentially.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0257-277X
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
333-41
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Impact of lymphocyte apoptosis on the innate immune stages of infection.
pubmed:affiliation
Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural