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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-11-21
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pubmed:abstractText |
Whereas growth factors, via their ability to stimulate vascular smooth muscle cell (VSMC) proliferation and migration, have been thought to play a permissive role in atherosclerosis initiation and progression, the role of insulin-like growth factor-1 (IGF-1) is unknown. Here we report for the first time that IGF-1 infusion decreased atherosclerotic plaque progression in ApoE-deficient mice on a Western diet.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-epi-prostaglandin F2alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins E,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Fats,
http://linkedlifedata.com/resource/pubmed/chemical/Dinoprost,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin-Like Growth Factor I,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type III,
http://linkedlifedata.com/resource/pubmed/chemical/Nos3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Superoxides,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4636
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2684-90
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17916769-Animals,
pubmed-meshheading:17916769-Anti-Inflammatory Agents,
pubmed-meshheading:17916769-Antioxidants,
pubmed-meshheading:17916769-Aorta,
pubmed-meshheading:17916769-Apolipoproteins E,
pubmed-meshheading:17916769-Atherosclerosis,
pubmed-meshheading:17916769-Cells, Cultured,
pubmed-meshheading:17916769-Dietary Fats,
pubmed-meshheading:17916769-Dinoprost,
pubmed-meshheading:17916769-Disease Models, Animal,
pubmed-meshheading:17916769-Disease Progression,
pubmed-meshheading:17916769-Endothelial Cells,
pubmed-meshheading:17916769-Humans,
pubmed-meshheading:17916769-Inflammation,
pubmed-meshheading:17916769-Insulin-Like Growth Factor I,
pubmed-meshheading:17916769-Interleukin-6,
pubmed-meshheading:17916769-Macrophages,
pubmed-meshheading:17916769-Mice,
pubmed-meshheading:17916769-Mice, Inbred C57BL,
pubmed-meshheading:17916769-Mice, Knockout,
pubmed-meshheading:17916769-Nitric Oxide Synthase Type II,
pubmed-meshheading:17916769-Nitric Oxide Synthase Type III,
pubmed-meshheading:17916769-Oxidative Stress,
pubmed-meshheading:17916769-Phosphorylation,
pubmed-meshheading:17916769-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17916769-RNA, Messenger,
pubmed-meshheading:17916769-Recombinant Proteins,
pubmed-meshheading:17916769-Stem Cells,
pubmed-meshheading:17916769-Superoxides,
pubmed-meshheading:17916769-Tumor Necrosis Factor-alpha
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pubmed:year |
2007
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pubmed:articleTitle |
IGF-1 reduces inflammatory responses, suppresses oxidative stress, and decreases atherosclerosis progression in ApoE-deficient mice.
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pubmed:affiliation |
Cardiology Section, Department of Medicine, Tulane University School of Medicine, 1430 Tulane Ave, SL-48, New Orleans, LA 70112, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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