|
rdf:type |
|
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lifeskim:mentions |
umls-concept:C0027950,
umls-concept:C0030685,
umls-concept:C0079411,
umls-concept:C0086418,
umls-concept:C0108282,
umls-concept:C0162772,
umls-concept:C0205263,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C0887943,
umls-concept:C1283071,
umls-concept:C1963578
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pubmed:issue |
6
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|
pubmed:dateCreated |
2007-11-20
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|
pubmed:abstractText |
Psoriasis is characterized by epidermal infiltration of neutrophils that destroy invading microorganisms via a potent antimicrobial arsenal of oxidants and antimicrobial agents. In contrast to atopic dermatitis, psoriasis exhibits low levels of skin infections due to the presence of antimicrobial agents, including cathelicidin LL-37. LL-37 kills a broad spectrum of microbes, and activates neutrophil chemotaxis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-0963
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
157
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1124-31
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17916212-Antioxidants,
pubmed-meshheading:17916212-Blotting, Western,
pubmed-meshheading:17916212-Cathelicidins,
pubmed-meshheading:17916212-Cells, Cultured,
pubmed-meshheading:17916212-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:17916212-Female,
pubmed-meshheading:17916212-Humans,
pubmed-meshheading:17916212-Interleukin-8,
pubmed-meshheading:17916212-Male,
pubmed-meshheading:17916212-Neutrophils,
pubmed-meshheading:17916212-Phosphorylation,
pubmed-meshheading:17916212-Reactive Oxygen Species,
pubmed-meshheading:17916212-alpha-Defensins,
pubmed-meshheading:17916212-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2007
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pubmed:articleTitle |
Cathelicidin LL-37 induces the generation of reactive oxygen species and release of human alpha-defensins from neutrophils.
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pubmed:affiliation |
Atopy (Allergy) Research Center, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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