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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-11-16
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pubmed:abstractText |
There is an emerging relationship between insulin resistance/hyperinsulinemia, oxidative stress, and glomerular injury manifesting as albuminuria. HMG-CoA reductase inhibitors (statins) have been shown to reduce oxidative stress in the vasculature as well as albuminuria in animal models and in human studies. The glomerular filtration barrier is emerging as a critical determinant of albumin filtration. We investigated the effects of insulin resistance and rosuvastatin or placebo on the glomerular filtration barrier.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1421-9670
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pubmed:author |
pubmed-author:CooperShawna ASA,
pubmed-author:DeMarcoVincent GVG,
pubmed-author:HaydenMelvin RMR,
pubmed-author:LastraGuidoG,
pubmed-author:ManriqueCamilaC,
pubmed-author:NistalaRaviR,
pubmed-author:SowersJames RJR,
pubmed-author:WeiYongzhongY,
pubmed-author:WesterlyBlairB,
pubmed-author:Whaley-ConnellAdamA,
pubmed-author:WiedmeyerCharlesC
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pubmed:copyrightInfo |
(c) 2007 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
67-75
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17914247-Albuminuria,
pubmed-meshheading:17914247-Animals,
pubmed-meshheading:17914247-Blood Glucose,
pubmed-meshheading:17914247-Body Weight,
pubmed-meshheading:17914247-Fluorobenzenes,
pubmed-meshheading:17914247-Glomerular Filtration Rate,
pubmed-meshheading:17914247-Homeostasis,
pubmed-meshheading:17914247-Hydroxymethylglutaryl-CoA Reductase Inhibitors,
pubmed-meshheading:17914247-Insulin,
pubmed-meshheading:17914247-Insulin Resistance,
pubmed-meshheading:17914247-Male,
pubmed-meshheading:17914247-Microscopy, Electron, Transmission,
pubmed-meshheading:17914247-Obesity,
pubmed-meshheading:17914247-Oxidative Stress,
pubmed-meshheading:17914247-Podocytes,
pubmed-meshheading:17914247-Pyrimidines,
pubmed-meshheading:17914247-Rats,
pubmed-meshheading:17914247-Rats, Zucker,
pubmed-meshheading:17914247-Sulfonamides,
pubmed-meshheading:17914247-Superoxide Dismutase
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pubmed:year |
2008
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pubmed:articleTitle |
Insulin resistance, oxidative stress, and podocyte injury: role of rosuvastatin modulation of filtration barrier injury.
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pubmed:affiliation |
Department of Internal Medicine, University of Missouri-Columbia School of Medicine, Columbia, MO 65212, USA. whaleyconnella@health.missouri.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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