Source:http://linkedlifedata.com/resource/pubmed/id/17912759
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2007-10-29
|
| pubmed:abstractText |
Anti-inflammatory gene therapy is promising in inflammatory diseases such as rheumatoid arthritis (RA). We have previously demonstrated that intra-muscular (i.m.) electrotransfer (ET) of plasmids encoding three different human tumor necrosis factor-alpha-soluble receptor I variants (hTNFR-Is) exert protective effects in an experimental RA model. However, such a systemic approach could be responsible for side effects. The present study aimed at performing an intra-articular (i.a.) gene therapy by electrotransfer using the hTNFR-Is plasmids.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1099-498X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
986-93
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| pubmed:meshHeading |
pubmed-meshheading:17912759-Animals,
pubmed-meshheading:17912759-Ankle,
pubmed-meshheading:17912759-Arthritis, Experimental,
pubmed-meshheading:17912759-Drug Delivery Systems,
pubmed-meshheading:17912759-Electroporation,
pubmed-meshheading:17912759-Gene Expression,
pubmed-meshheading:17912759-Gene Therapy,
pubmed-meshheading:17912759-Humans,
pubmed-meshheading:17912759-Inflammation,
pubmed-meshheading:17912759-Joints,
pubmed-meshheading:17912759-Mice,
pubmed-meshheading:17912759-Plasmids,
pubmed-meshheading:17912759-Receptors, Tumor Necrosis Factor, Type I
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
Intra-articular electrotransfer of plasmid encoding soluble TNF receptor variants in normal and arthritic mice.
|
| pubmed:affiliation |
Inserm, Eri-18, F-93017 Bobigny, France.
|
| pubmed:publicationType |
Journal Article
|