pubmed-article:17910616 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0030020 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0036140 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0037643 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C2348767 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0062699 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0075762 | lld:lifeskim |
pubmed-article:17910616 | lifeskim:mentions | umls-concept:C0164843 | lld:lifeskim |
pubmed-article:17910616 | pubmed:issue | 5 | lld:pubmed |
pubmed-article:17910616 | pubmed:dateCreated | 2007-10-3 | lld:pubmed |
pubmed-article:17910616 | pubmed:abstractText | The reactivating and therapeutic efficacy of two salts of the oxime HI-6 (dichloride and dimethanesulphonate) against chosen nerve agents (tabun, soman and cyclosarin) was compared in rats. The potency of both salts of HI-6 to decrease the acute toxicity of tabun, soman and cyclosarin was similar in nerve agent-poisoned rats. While the potency of HI-6 dichloride and HI-6 dimethanesulphonate to counteract acute toxic effects of tabun is rather low, both salts of HI-6 were able to decrease the acute toxicity of soman two times and acute toxicity of cyclosarin more than three times. The therapeutic efficacy of both salts of the oxime HI-6 corresponds to their reactivating potency. While the reactivating efficacy of HI-6 dichloride as well as HI-6 dimethanesulphonate against tabun was negligible, their potency to reactivate soman-inhibited acetylcholinesterase and cyclosarin-inhibited acetylcholinesterase in peripheral (blood) and central (brain) compartment was relatively high. HI-6 dichloride showed a somewhat higher potency to reactivate tabun-inhibited acetylcholinesterase in brain, and soman-inhibited acetylcholinesterase in blood and brain than HI-6 dimethanesulphonate but the differences were not significant. Thus, the replacement of dichloride anion by dimethanesulphonate anion in the oxime HI-6 does not influence the therapeutic and reactivating efficacy of the oxime HI-6 against nerve agents. In addition, the higher solubility and stability of HI-6 dimethanesulphonate in comparison with HI-6 dichloride makes it possible to increase the dose and thus, the effectiveness of the oxime HI-6 in the antidotal treatment of acute nerve agent poisonings. | lld:pubmed |
pubmed-article:17910616 | pubmed:language | eng | lld:pubmed |
pubmed-article:17910616 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:17910616 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:17910616 | pubmed:month | Nov | lld:pubmed |
pubmed-article:17910616 | pubmed:issn | 1742-7835 | lld:pubmed |
pubmed-article:17910616 | pubmed:author | pubmed-author:KucaKamilK | lld:pubmed |
pubmed-article:17910616 | pubmed:author | pubmed-author:BajgarJiriJ | lld:pubmed |
pubmed-article:17910616 | pubmed:author | pubmed-author:KassaJiriJ | lld:pubmed |
pubmed-article:17910616 | pubmed:author | pubmed-author:JunDanielD | lld:pubmed |
pubmed-article:17910616 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:17910616 | pubmed:volume | 101 | lld:pubmed |
pubmed-article:17910616 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:17910616 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:17910616 | pubmed:pagination | 328-32 | lld:pubmed |
pubmed-article:17910616 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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pubmed-article:17910616 | pubmed:year | 2007 | lld:pubmed |
pubmed-article:17910616 | pubmed:articleTitle | Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats. | lld:pubmed |
pubmed-article:17910616 | pubmed:affiliation | Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebresska 1575, 500 01 Hradec Kralove, Czech Republic. kassa@pmfhk.cz | lld:pubmed |
pubmed-article:17910616 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:17910616 | pubmed:publicationType | Comparative Study | lld:pubmed |
pubmed-article:17910616 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |