Linked Life Data

17910616

Source:http://linkedlifedata.com/resource/pubmed/id/17910616

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-10-3
pubmed:abstractText
The reactivating and therapeutic efficacy of two salts of the oxime HI-6 (dichloride and dimethanesulphonate) against chosen nerve agents (tabun, soman and cyclosarin) was compared in rats. The potency of both salts of HI-6 to decrease the acute toxicity of tabun, soman and cyclosarin was similar in nerve agent-poisoned rats. While the potency of HI-6 dichloride and HI-6 dimethanesulphonate to counteract acute toxic effects of tabun is rather low, both salts of HI-6 were able to decrease the acute toxicity of soman two times and acute toxicity of cyclosarin more than three times. The therapeutic efficacy of both salts of the oxime HI-6 corresponds to their reactivating potency. While the reactivating efficacy of HI-6 dichloride as well as HI-6 dimethanesulphonate against tabun was negligible, their potency to reactivate soman-inhibited acetylcholinesterase and cyclosarin-inhibited acetylcholinesterase in peripheral (blood) and central (brain) compartment was relatively high. HI-6 dichloride showed a somewhat higher potency to reactivate tabun-inhibited acetylcholinesterase in brain, and soman-inhibited acetylcholinesterase in blood and brain than HI-6 dimethanesulphonate but the differences were not significant. Thus, the replacement of dichloride anion by dimethanesulphonate anion in the oxime HI-6 does not influence the therapeutic and reactivating efficacy of the oxime HI-6 against nerve agents. In addition, the higher solubility and stability of HI-6 dimethanesulphonate in comparison with HI-6 dichloride makes it possible to increase the dose and thus, the effectiveness of the oxime HI-6 in the antidotal treatment of acute nerve agent poisonings.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Atropine, http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Reactivators, http://linkedlifedata.com/resource/pubmed/chemical/HI 6, http://linkedlifedata.com/resource/pubmed/chemical/Muscarinic Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Oximes, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Acid Esters, http://linkedlifedata.com/resource/pubmed/chemical/Pyridinium Compounds, http://linkedlifedata.com/resource/pubmed/chemical/Soman, http://linkedlifedata.com/resource/pubmed/chemical/cyclohexyl methylphosphonofluoridate, http://linkedlifedata.com/resource/pubmed/chemical/tabun
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1742-7835
pubmed:author
pubmed:issnType
Print
pubmed:volume
101
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
328-32
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Comparison of reactivating and therapeutic efficacy of two salts of the oxime HI-6 against tabun, soman and cyclosarin in rats.
pubmed:affiliation
Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebresska 1575, 500 01 Hradec Kralove, Czech Republic. kassa@pmfhk.cz
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't