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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2007-10-16
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pubmed:abstractText |
T lymphocytes are thought to be important in atherosclerosis, but very little is known about the mechanisms of lymphocyte recruitment into atherosclerosis-prone aortas. In this study we tested the hypothesis that CXCR6, a chemokine receptor that is expressed on a subset of CD4+ T helper 1 cells and natural killer T cells, is involved in lymphocyte homing into the aortic wall and modulates the development and progression of atherosclerosis.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1801-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17909108-Animals,
pubmed-meshheading:17909108-Aortic Diseases,
pubmed-meshheading:17909108-Apolipoproteins E,
pubmed-meshheading:17909108-Atherosclerosis,
pubmed-meshheading:17909108-Female,
pubmed-meshheading:17909108-Green Fluorescent Proteins,
pubmed-meshheading:17909108-Humans,
pubmed-meshheading:17909108-Interferon-gamma,
pubmed-meshheading:17909108-Macrophages,
pubmed-meshheading:17909108-Male,
pubmed-meshheading:17909108-Mice,
pubmed-meshheading:17909108-Mice, Inbred C57BL,
pubmed-meshheading:17909108-Mice, Transgenic,
pubmed-meshheading:17909108-Protein Transport,
pubmed-meshheading:17909108-Receptors, CXCR,
pubmed-meshheading:17909108-T-Lymphocytes
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pubmed:year |
2007
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pubmed:articleTitle |
CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wall.
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pubmed:affiliation |
Department of Biomedical Engineering and Robert M. Berne Cardiovascular Research Center, University of Virginia, Health Sciences Center, Charlottesville, VA 22908, USA. evg7c@virginia.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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