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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2007-10-2
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pubmed:abstractText |
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/Apo-2L promotes apoptosis in cancer cells while sparing normal cells. Although many cancers are sensitive to TRAIL-induced apoptosis, some evade the proapoptotic effects of TRAIL. Therefore, differentiating molecular mechanisms that distinguish between TRAIL-sensitive and TRAIL-resistant tumors are essential for effective cancer therapies. Here, we show that c-Fos functions as a proapoptotic agent by repressing the antiapoptotic molecule c-FLIP(L). c-Fos binds the c-FLIP(L) promoter, represses its transcriptional activity, and reduces c-FLIP(L) mRNA and protein levels. Therefore, c-Fos is a key regulator of c-FLIP(L), and activation of c-Fos determines whether a cancer cell will undergo cell death after TRAIL treatment. Strategies to activate c-Fos or inhibit c-FLIP(L) may potentiate TRAIL-based proapoptotic therapies.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0008-5472
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
67
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
9425-34
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pubmed:dateRevised |
2011-4-22
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pubmed:meshHeading |
pubmed-meshheading:17909052-Animals,
pubmed-meshheading:17909052-Apoptosis,
pubmed-meshheading:17909052-CASP8 and FADD-Like Apoptosis Regulating Protein,
pubmed-meshheading:17909052-Cell Line, Tumor,
pubmed-meshheading:17909052-Cell Nucleus,
pubmed-meshheading:17909052-Drug Resistance, Neoplasm,
pubmed-meshheading:17909052-Humans,
pubmed-meshheading:17909052-Male,
pubmed-meshheading:17909052-Mice,
pubmed-meshheading:17909052-Mice, Nude,
pubmed-meshheading:17909052-Prostatic Neoplasms,
pubmed-meshheading:17909052-Proto-Oncogene Proteins c-fos,
pubmed-meshheading:17909052-RNA, Messenger,
pubmed-meshheading:17909052-Recombinant Proteins,
pubmed-meshheading:17909052-TNF-Related Apoptosis-Inducing Ligand,
pubmed-meshheading:17909052-Transcription Factor AP-1,
pubmed-meshheading:17909052-Xenograft Model Antitumor Assays
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pubmed:year |
2007
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pubmed:articleTitle |
c-Fos as a proapoptotic agent in TRAIL-induced apoptosis in prostate cancer cells.
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pubmed:affiliation |
Department of Urology, Massachusetts General Hospital, Boston, MA 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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