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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-11-20
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pubmed:abstractText |
Antileishmanial activities of 91 synthetic phospholipids against Leishmania donovani were evaluated in vitro and cytotoxicity assessed against two mammalian cell lines. Promising compounds were tested further in vivo. In vitro structure-activity relationships showed a positive contribution of head groups bearing ring systems (N-methylpiperidino and N-methylmorpholino) to antileishmanial activity.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-11801222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-12150849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-12593656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-12615315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-14522101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-15378809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-16310148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-16418332,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-16730362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-17158053,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-2272038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-3574353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-7630930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17908944-9023651
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
51
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4525-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17908944-Animals,
pubmed-meshheading:17908944-Antiprotozoal Agents,
pubmed-meshheading:17908944-Cell Line, Tumor,
pubmed-meshheading:17908944-Cell Survival,
pubmed-meshheading:17908944-Cricetinae,
pubmed-meshheading:17908944-Humans,
pubmed-meshheading:17908944-Inhibitory Concentration 50,
pubmed-meshheading:17908944-Leishmania donovani,
pubmed-meshheading:17908944-Lethal Dose 50,
pubmed-meshheading:17908944-Molecular Structure,
pubmed-meshheading:17908944-Phospholipids,
pubmed-meshheading:17908944-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Antileishmanial structure-activity relationships of synthetic phospholipids: in vitro and in vivo activities of selected derivatives.
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pubmed:affiliation |
Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom. karin.seifert@lshtm.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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