Source:http://linkedlifedata.com/resource/pubmed/id/17905744
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2008-1-25
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| pubmed:abstractText |
Little is known regarding how alkali metal ions are transported in the olfactory nerve following their intranasal administration. In this study, we show that an alkali metal ion, thallium is transported in the olfactory nerve fibers to the olfactory bulb in mice. The olfactory nerve fibers of mice were transected on both sides of the body under anesthesia. A double tracer solution (thallium-201, (201)Tl; manganese-54, (54)Mn) was administered into the nasal cavity the following day. Radioactivity in the olfactory bulb and nasal turbinate was analyzed with gamma spectrometry. Auto radiographic images were obtained from coronal slices of frozen heads of mice administered with (201)Tl or (54)Mn. The transection of the olfactory nerve fibers was confirmed with a neuronal tracer. The transport of intranasal administered (201)Tl/(54)Mn to the olfactory bulb was significantly reduced by the transection of olfactory nerve fibers. The olfactory nerve transection also significantly inhibited the accumulation of fluoro-ruby in the olfactory bulb. Findings indicate that thallium is transported by the olfactory nerve fibers to the olfactory bulb in mice. The assessment of thallium transport following head injury may provide a new diagnostic method for the evaluation of olfactory nerve injury.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Dextrans,
http://linkedlifedata.com/resource/pubmed/chemical/Fluorescent Dyes,
http://linkedlifedata.com/resource/pubmed/chemical/Fluoro-Ruby,
http://linkedlifedata.com/resource/pubmed/chemical/Manganese,
http://linkedlifedata.com/resource/pubmed/chemical/Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Rhodamines,
http://linkedlifedata.com/resource/pubmed/chemical/Thallium Radioisotopes
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
0379-864X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
33
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
73-8
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:17905744-Administration, Intranasal,
pubmed-meshheading:17905744-Animals,
pubmed-meshheading:17905744-Autoradiography,
pubmed-meshheading:17905744-Axonal Transport,
pubmed-meshheading:17905744-Cranial Nerve Injuries,
pubmed-meshheading:17905744-Dextrans,
pubmed-meshheading:17905744-Fluorescent Dyes,
pubmed-meshheading:17905744-Kinetics,
pubmed-meshheading:17905744-Male,
pubmed-meshheading:17905744-Manganese,
pubmed-meshheading:17905744-Mice,
pubmed-meshheading:17905744-Mice, Inbred ICR,
pubmed-meshheading:17905744-Nasal Cavity,
pubmed-meshheading:17905744-Olfactory Bulb,
pubmed-meshheading:17905744-Olfactory Nerve,
pubmed-meshheading:17905744-Olfactory Nerve Injuries,
pubmed-meshheading:17905744-Radioisotopes,
pubmed-meshheading:17905744-Rhodamines,
pubmed-meshheading:17905744-Thallium Radioisotopes,
pubmed-meshheading:17905744-Tissue Distribution
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| pubmed:year |
2008
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| pubmed:articleTitle |
Thallium transport and the evaluation of olfactory nerve connectivity between the nasal cavity and olfactory bulb.
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| pubmed:affiliation |
Department of Otorhinolaryngology, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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