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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-10-8
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pubmed:abstractText |
In this study, we investigated the interactions between synapse adhesion molecules neurexin, neuroligin1, neuroligin2 and postsynaptic density protein 95 (PSD-95) in transient cerebral ischemia and possible regulatory mechanism of these interactions. Our data show that preconditioning ischemia can down-regulate the increased neurexin-neuroligin1-PSD-95 interaction induced by ischemia injury and exerts a neuroprotective effect. Pre-treatment of N-methyl-D-aspartate (NMDA) receptor antagonist ketamine can demolish this neuroprotective effect of preconditioning by increasing neurexin-neuroligin1-PSD-95 interaction. These results indicate that the neurexin-neuroligin1-PSD-95 is an important signalling module in ischemic injury and a novel possible target in therapeutics of brain ischemia.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules, Neuronal,
http://linkedlifedata.com/resource/pubmed/chemical/Dlgh4 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Excitatory Amino Acid Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Intracellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ketamine,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nerve Tissue Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, N-Methyl-D-Aspartate,
http://linkedlifedata.com/resource/pubmed/chemical/neuroligin 1
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3940
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
426
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
192-7
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pubmed:meshHeading |
pubmed-meshheading:17904739-Animals,
pubmed-meshheading:17904739-Blotting, Western,
pubmed-meshheading:17904739-Cell Adhesion Molecules, Neuronal,
pubmed-meshheading:17904739-Excitatory Amino Acid Antagonists,
pubmed-meshheading:17904739-Hippocampus,
pubmed-meshheading:17904739-Immunoprecipitation,
pubmed-meshheading:17904739-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:17904739-Ischemic Attack, Transient,
pubmed-meshheading:17904739-Ischemic Preconditioning,
pubmed-meshheading:17904739-Ketamine,
pubmed-meshheading:17904739-Male,
pubmed-meshheading:17904739-Membrane Proteins,
pubmed-meshheading:17904739-Nerve Tissue Proteins,
pubmed-meshheading:17904739-Rats,
pubmed-meshheading:17904739-Rats, Sprague-Dawley,
pubmed-meshheading:17904739-Receptors, N-Methyl-D-Aspartate,
pubmed-meshheading:17904739-Synapses
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pubmed:year |
2007
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pubmed:articleTitle |
Preconditioning ischemia attenuates increased neurexin-neuroligin1-PSD-95 interaction after transient cerebral ischemia in rat hippocampus.
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pubmed:affiliation |
Research Center for Biochemistry and Molecular Biology and Provincial Key Laboratory of Brain Disease Bioinformation, Xuzhou Medical College, 84 West Huai-hai Road, Xuzhou, Jiangsu 221002, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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