Source:http://linkedlifedata.com/resource/pubmed/id/17902150
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2007-12-19
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pubmed:abstractText |
Oral squamous cell carcinoma (OSCC) is a disfiguring and deadly cancer. Despite advances in therapy, many patients continue to face a poor prognosis. Early detection is an important factor in determining the survival of patients with OSCC. No accurate, cost-efficient, and reproducible method exists to screen patients for OSCC. As a result, many patients are diagnosed at advanced stages of the disease. Early detection would identify patients, facilitating timely treatment and close monitoring. Mass screening requires a rapid oral cancer diagnostic test that can be used in a clinical setting. Current diagnostic techniques for OSCC require modern laboratory facilities, sophisticated equipment, and elaborate and lengthy processing by skilled personnel. The lab-on-chip technology holds the promise of replacing these techniques with miniaturized, integrated, automated, inexpensive diagnostic devices. This article describes lab-on-chip devices for biomarker-based identification of oral cancer. Similar methods can be employed for the screening of other types of cancers.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cell Adhesion Molecules,
http://linkedlifedata.com/resource/pubmed/chemical/EPCAM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/colligin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1043-3074
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pubmed:author | |
pubmed:copyrightInfo |
Copyright (c) 2007 Wiley Periodicals, Inc.
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
111-21
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pubmed:dateRevised |
2011-10-28
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pubmed:meshHeading |
pubmed-meshheading:17902150-Antigens, Neoplasm,
pubmed-meshheading:17902150-Carcinoma, Squamous Cell,
pubmed-meshheading:17902150-Carrier Proteins,
pubmed-meshheading:17902150-Cell Adhesion Molecules,
pubmed-meshheading:17902150-Gene Expression Profiling,
pubmed-meshheading:17902150-Humans,
pubmed-meshheading:17902150-Mass Screening,
pubmed-meshheading:17902150-Microfluidic Analytical Techniques,
pubmed-meshheading:17902150-Mouth Neoplasms,
pubmed-meshheading:17902150-RNA, Messenger,
pubmed-meshheading:17902150-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17902150-Software,
pubmed-meshheading:17902150-Transcription, Genetic,
pubmed-meshheading:17902150-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Lab-on-a-chip for oral cancer screening and diagnosis.
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pubmed:affiliation |
Department of Otorhinolaryngology, School of Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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