Source:http://linkedlifedata.com/resource/pubmed/id/17902128
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2007-10-3
|
| pubmed:abstractText |
Hepatitis C virus (HCV) has been proposed to have immunomodulatory effects in transplant recipients and may promote herpesvirus reactivation. To assess this, we compared the incidence of herpesvirus reactivation in HCV-positive and HCV-negative liver transplant recipients. Quantitative viral load testing was performed at regular intervals posttransplantation for cytomegalovirus (CMV), Epstein-Barr virus (EBV), human herpesviruses (HHV) 6, 7, and 8, and varicella zoster virus (VZV) in 177 liver transplant patients who were HCV-positive (n=60) or HCV-negative (n=117). The incidence of CMV disease, CMV viremia, and the peak CMV viral load was not significantly different in HCV-positive vs. HCV-negative patients. Similarly, no differences in HHV-6 or EBV reactivation were observed. HHV-8 or VZV viremia was not detected in any patient in the study. A lower incidence of HHV-7 infection occurred in HCV-positive patients vs. HCV-negative patients (47.6% vs. 72.7%; P=0.006). In conclusion, these results suggest that HCV infection does not appear to promote herpesvirus reactivation after liver transplantation.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Oct
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| pubmed:issn |
1527-6465
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| pubmed:author | |
| pubmed:copyrightInfo |
Copyright (c) 2007 AASLD.
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| pubmed:issnType |
Print
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| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1422-7
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| pubmed:meshHeading |
pubmed-meshheading:17902128-Adolescent,
pubmed-meshheading:17902128-Adult,
pubmed-meshheading:17902128-Aged,
pubmed-meshheading:17902128-Female,
pubmed-meshheading:17902128-Follow-Up Studies,
pubmed-meshheading:17902128-Hepacivirus,
pubmed-meshheading:17902128-Hepatitis C,
pubmed-meshheading:17902128-Hepatitis C Antibodies,
pubmed-meshheading:17902128-Herpesviridae,
pubmed-meshheading:17902128-Herpesviridae Infections,
pubmed-meshheading:17902128-Humans,
pubmed-meshheading:17902128-Incidence,
pubmed-meshheading:17902128-Liver Failure,
pubmed-meshheading:17902128-Liver Transplantation,
pubmed-meshheading:17902128-Male,
pubmed-meshheading:17902128-Middle Aged,
pubmed-meshheading:17902128-Viral Load,
pubmed-meshheading:17902128-Virus Activation,
pubmed-meshheading:17902128-Virus Replication
|
| pubmed:year |
2007
|
| pubmed:articleTitle |
An assessment of interactions between hepatitis C virus and herpesvirus reactivation in liver transplant recipients using molecular surveillance.
|
| pubmed:affiliation |
Department of Medicine, University of Alberta, Edmonton, AB, Canada. ahumar@ualberta.ca
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|