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rdf:type |
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lifeskim:mentions |
umls-concept:C0006142,
umls-concept:C0032854,
umls-concept:C0034840,
umls-concept:C0085862,
umls-concept:C0220901,
umls-concept:C0237881,
umls-concept:C0750502,
umls-concept:C1274040,
umls-concept:C1299583,
umls-concept:C1334871,
umls-concept:C1522602,
umls-concept:C1549571,
umls-concept:C1561558,
umls-concept:C1608386
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pubmed:issue |
3
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pubmed:dateCreated |
2008-7-9
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pubmed:abstractText |
Advances in understanding the molecular basis of breast cancer has necessitated a definition of improved indicators of prognosis that are central to the underlying cancer biology and that reflect the heterogeneous nature of the disease. This study investigates the pattern of expression of the steroid receptor co-regulators NCOA1/SRC1, NCOA3/RAC3, NCOR2/SMRT, and CBP/p300 in breast cancer. The aims were to identify whether their expression was related to patient outcome, their relationships to known prognostic factors and to provide a basis for further research into the mechanistic significance of such associations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Acetyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NCOA3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NCOR2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Co-Repressor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 1,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Receptor Coactivator 3,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/p300-CBP Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0167-6806
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
427-37
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17902051-Breast Neoplasms,
pubmed-meshheading:17902051-DNA-Binding Proteins,
pubmed-meshheading:17902051-Female,
pubmed-meshheading:17902051-Histone Acetyltransferases,
pubmed-meshheading:17902051-Humans,
pubmed-meshheading:17902051-Immunohistochemistry,
pubmed-meshheading:17902051-Kaplan-Meier Estimate,
pubmed-meshheading:17902051-Middle Aged,
pubmed-meshheading:17902051-Nuclear Receptor Co-Repressor 2,
pubmed-meshheading:17902051-Nuclear Receptor Coactivator 1,
pubmed-meshheading:17902051-Nuclear Receptor Coactivator 3,
pubmed-meshheading:17902051-Prognosis,
pubmed-meshheading:17902051-Repressor Proteins,
pubmed-meshheading:17902051-Tissue Array Analysis,
pubmed-meshheading:17902051-Trans-Activators,
pubmed-meshheading:17902051-Transcription Factors,
pubmed-meshheading:17902051-Treatment Outcome,
pubmed-meshheading:17902051-Tumor Markers, Biological,
pubmed-meshheading:17902051-p300-CBP Transcription Factors
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pubmed:year |
2008
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pubmed:articleTitle |
The prognostic significance of steroid receptor co-regulators in breast cancer: co-repressor NCOR2/SMRT is an independent indicator of poor outcome.
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pubmed:affiliation |
Division of Pathology, School of Molecular Medical Sciences, Nottingham University Hospitals NHS and University of Nottingham, Nottingham, UK. andrew.green@nottingham.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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