Source:http://linkedlifedata.com/resource/pubmed/id/17901577
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2007-9-28
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| pubmed:abstractText |
The exact role of compounds modulating nitric oxide (NO) content in the brain during seizure phenomena is under intensive investigation. This study was aimed at determining the effect of NG-nitro-L-arginine (L-NA; a non-selective NO synthase inhibitor) on the anticonvulsant activity of four second-generation antiepileptic drugs (AEDs: gabapentin [GBP], oxcarbazepine [OXC], tiagabine [TGB] and vigabatrin [VGB]) in the mouse pentetrazole (PTZ)-induced seizure model. The acute adverse-effect liability of the studied AEDs in combinations with L-NA were evaluated in the chimney test (motor coordination). Results indicate that L-NA (40 mg/kg; ip) significantly reduced the anticonvulsant activity of OXC in the PTZ test, by increasing its ED50 from 20.9 to 29.8 mg/kg (p < 0.05). Similarly, L-NA at doses of 20 and 40 mg/kg considerably attenuated the antiseizure effects of VGB by raising its ED50 from 595 to 930 mg/kg (p < 0.05), and 1022 mg/kg (p < 0.01), respectively. L-NA at lower doses of 10 and 20 mg/kg did not affect significantly the anticonvulsant effects of VGB and OXC in PTZ-induced seizures. Likewise, the co-administration of L-NA(40 mg/kg; ip) with GBP and TGB was associated with no significant changes in their anticonvulsant activities in PTZ-induced seizures in mice. Moreover, none of the examined combinations of L-NA (40 mg/kg; ip) and second-generation AEDs (at their ED50 values) affected motor coordination in the chimney test. Based on this preclinical study, one can conclude that L-NA reduced the anticonvulsant activities of VGB and OXC in the mouse PTZ-induced seizure model. Only, GBP and TGB were resistant to the action of L-NA in this model.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Amines,
http://linkedlifedata.com/resource/pubmed/chemical/Anticonvulsants,
http://linkedlifedata.com/resource/pubmed/chemical/Carbamazepine,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclohexanecarboxylic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Nipecotic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitroarginine,
http://linkedlifedata.com/resource/pubmed/chemical/Pentylenetetrazole,
http://linkedlifedata.com/resource/pubmed/chemical/Vigabatrin,
http://linkedlifedata.com/resource/pubmed/chemical/gabapentin,
http://linkedlifedata.com/resource/pubmed/chemical/gamma-Aminobutyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/oxcarbazepine,
http://linkedlifedata.com/resource/pubmed/chemical/tiagabine
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| pubmed:status |
MEDLINE
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| pubmed:issn |
1734-1140
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
59
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
467-73
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| pubmed:dateRevised |
2008-5-28
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| pubmed:meshHeading |
pubmed-meshheading:17901577-Amines,
pubmed-meshheading:17901577-Animals,
pubmed-meshheading:17901577-Anticonvulsants,
pubmed-meshheading:17901577-Behavior, Animal,
pubmed-meshheading:17901577-Carbamazepine,
pubmed-meshheading:17901577-Cyclohexanecarboxylic Acids,
pubmed-meshheading:17901577-Disease Models, Animal,
pubmed-meshheading:17901577-Dose-Response Relationship, Drug,
pubmed-meshheading:17901577-Enzyme Inhibitors,
pubmed-meshheading:17901577-Injections, Intraperitoneal,
pubmed-meshheading:17901577-Injections, Subcutaneous,
pubmed-meshheading:17901577-Male,
pubmed-meshheading:17901577-Mice,
pubmed-meshheading:17901577-Nipecotic Acids,
pubmed-meshheading:17901577-Nitric Oxide Synthase,
pubmed-meshheading:17901577-Nitroarginine,
pubmed-meshheading:17901577-Pentylenetetrazole,
pubmed-meshheading:17901577-Psychomotor Performance,
pubmed-meshheading:17901577-Seizures,
pubmed-meshheading:17901577-Time Factors,
pubmed-meshheading:17901577-Vigabatrin,
pubmed-meshheading:17901577-gamma-Aminobutyric Acid
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| pubmed:articleTitle |
Effect of NG-nitro-L-arginine on the anticonvulsant action of four second-generation antiepileptic drugs in pentetrazole-induced clonic seizures in mice.
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| pubmed:affiliation |
Department of Pathophysiology, Medical Institute of Lublin, Jaczewskiego 8, PL 20-090 Lublin, Poland. jarogniew.luszczki@am.lublin.pl
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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