| pubmed-article:17901403 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0024501 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0038250 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0026900 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C2350292 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0599851 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C1113654 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0596290 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C0072473 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:17901403 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:17901403 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17901403 | pubmed:dateCreated | 2008-1-14 | lld:pubmed |
| pubmed-article:17901403 | pubmed:abstractText | Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain. | lld:pubmed |
| pubmed-article:17901403 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17901403 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17901403 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17901403 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:17901403 | pubmed:issn | 1549-4918 | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:YangQingQ | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:RamsayRobert... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:FramptonJonJ | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:TurnleyAnn... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:NicholsNancy... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:Mantamadiotis... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:MalaterreJord... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:DworkinSebast... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:EmambokusNikl... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:RansomeMark... | lld:pubmed |
| pubmed-article:17901403 | pubmed:author | pubmed-author:LightowlerSal... | lld:pubmed |
| pubmed-article:17901403 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17901403 | pubmed:volume | 26 | lld:pubmed |
| pubmed-article:17901403 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17901403 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17901403 | pubmed:pagination | 173-81 | lld:pubmed |
| pubmed-article:17901403 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17901403 | pubmed:meshHeading | pubmed-meshheading:17901403... | lld:pubmed |
| pubmed-article:17901403 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17901403 | pubmed:articleTitle | c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain. | lld:pubmed |
| pubmed-article:17901403 | pubmed:affiliation | Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. | lld:pubmed |
| pubmed-article:17901403 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17901403 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:17863 | entrezgene:pubmed | pubmed-article:17901403 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:17901403 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17901403 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17901403 | lld:pubmed |
