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rdf:type |
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lifeskim:mentions |
umls-concept:C0001675,
umls-concept:C0006104,
umls-concept:C0024501,
umls-concept:C0026900,
umls-concept:C0038250,
umls-concept:C0072473,
umls-concept:C0596290,
umls-concept:C0599851,
umls-concept:C1113654,
umls-concept:C1514873,
umls-concept:C1546857,
umls-concept:C1556066,
umls-concept:C1619636,
umls-concept:C2350292
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pubmed:issue |
1
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pubmed:dateCreated |
2008-1-14
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pubmed:abstractText |
Ongoing production of neurons in adult brain is restricted to specialized neurogenic niches. Deregulated expression of genes controlling homeostasis of neural progenitor cell division and/or their microenvironment underpins a spectrum of brain pathologies. Using conditional gene deletion, we show that the proto-oncogene c-myb regulates neural progenitor cell proliferation and maintains ependymal cell integrity in mice. These two cellular compartments constitute the neurogenic niche in the adult brain. Brains devoid of c-Myb showed enlarged ventricular spaces, ependymal cell abnormalities, and reduced neurogenesis. Neural progenitor cells lacking c-Myb showed a reduced intrinsic proliferative capacity and reduction of Sox-2 and Pax-6 expression. These data point to an important role for c-Myb in the neurogenic niche of the adult brain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Eye Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PAX6 protein,
http://linkedlifedata.com/resource/pubmed/chemical/Paired Box Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SOXB1 Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Sox2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1549-4918
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pubmed:author |
pubmed-author:DworkinSebastianS,
pubmed-author:EmambokusNikla RNR,
pubmed-author:FramptonJonJ,
pubmed-author:LightowlerSallyS,
pubmed-author:MalaterreJordaneJ,
pubmed-author:MantamadiotisTheoT,
pubmed-author:NicholsNancy RNR,
pubmed-author:RamsayRobert GRG,
pubmed-author:RansomeMark IMI,
pubmed-author:TurnleyAnn MAM,
pubmed-author:YangQingQ
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-81
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17901403-Adult Stem Cells,
pubmed-meshheading:17901403-Animals,
pubmed-meshheading:17901403-Brain,
pubmed-meshheading:17901403-Cell Count,
pubmed-meshheading:17901403-Cell Differentiation,
pubmed-meshheading:17901403-Cell Proliferation,
pubmed-meshheading:17901403-DNA-Binding Proteins,
pubmed-meshheading:17901403-Eye Proteins,
pubmed-meshheading:17901403-Gene Expression,
pubmed-meshheading:17901403-Gene Expression Regulation,
pubmed-meshheading:17901403-Genes, myb,
pubmed-meshheading:17901403-Homeodomain Proteins,
pubmed-meshheading:17901403-Immunohistochemistry,
pubmed-meshheading:17901403-In Situ Hybridization,
pubmed-meshheading:17901403-In Situ Nick-End Labeling,
pubmed-meshheading:17901403-Mice,
pubmed-meshheading:17901403-Microscopy, Electron, Scanning,
pubmed-meshheading:17901403-Neurons,
pubmed-meshheading:17901403-Paired Box Transcription Factors,
pubmed-meshheading:17901403-RNA, Messenger,
pubmed-meshheading:17901403-Repressor Proteins,
pubmed-meshheading:17901403-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17901403-SOXB1 Transcription Factors,
pubmed-meshheading:17901403-Trans-Activators
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pubmed:year |
2008
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pubmed:articleTitle |
c-Myb is required for neural progenitor cell proliferation and maintenance of the neural stem cell niche in adult brain.
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pubmed:affiliation |
Differentiation and Transcription Laboratory, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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