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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24
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pubmed:dateCreated |
2007-10-22
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pubmed:abstractText |
Enantiopure constrained 1-aminocyclopentane-1,2,4-tricarboxylic acids containing the glutamic acid skeleton were prepared as two diastereomers characterized by having the carboxylic groups in position two and four cis-oriented to each other and trans with respect to 1-carboxylic group and all cis-oriented carboxylic groups, respectively. A biochemical screening of activity of the above amino acids was investigated on glutamate and 5-HT receptors to find a possible metabotropic agonist, acting on the serotoninergic system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1464-3391
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7581-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17900912-Animals,
pubmed-meshheading:17900912-Cells, Cultured,
pubmed-meshheading:17900912-Cyclopentanes,
pubmed-meshheading:17900912-Drug Evaluation, Preclinical,
pubmed-meshheading:17900912-Humans,
pubmed-meshheading:17900912-Molecular Structure,
pubmed-meshheading:17900912-Rats,
pubmed-meshheading:17900912-Receptors, Glutamate,
pubmed-meshheading:17900912-Receptors, Serotonin,
pubmed-meshheading:17900912-Serotonin Receptor Agonists,
pubmed-meshheading:17900912-Stereoisomerism,
pubmed-meshheading:17900912-Tricarboxylic Acids
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pubmed:year |
2007
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pubmed:articleTitle |
1-Aminocyclopentane-1,2,4-tricarboxylic acids screening on glutamatergic and serotonergic systems.
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pubmed:affiliation |
Istituto di Chimica Organica "A. Marchesini", Facoltà di Farmacia, Università di Milano, Via Venezian 21, I-20133 Milano, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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