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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2007-11-9
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pubmed:abstractText |
Mitogenic activity of insulin and insulin analogues and the involvement of the IGF-1 receptor (IGF-1R) is still a controversial issue. We compared levels of the proteins IGF-1R and insulin receptor (InsR) in fibroblasts and smooth muscle cells from healthy donors and assessed the downstream signalling and growth-promoting activity of insulin and insulin analogues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin, Long-Acting,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Aspart,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin Lispro,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogens,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, IGF Type 1,
http://linkedlifedata.com/resource/pubmed/chemical/glargine,
http://linkedlifedata.com/resource/pubmed/chemical/insulin, Asp(B10)-,
http://linkedlifedata.com/resource/pubmed/chemical/insulin glulisine
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0012-186X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2534-43
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17898992-Adolescent,
pubmed-meshheading:17898992-Adult,
pubmed-meshheading:17898992-Cell Proliferation,
pubmed-meshheading:17898992-Cells, Cultured,
pubmed-meshheading:17898992-Child,
pubmed-meshheading:17898992-Female,
pubmed-meshheading:17898992-Fibroblasts,
pubmed-meshheading:17898992-Humans,
pubmed-meshheading:17898992-Insulin,
pubmed-meshheading:17898992-Insulin, Long-Acting,
pubmed-meshheading:17898992-Insulin Aspart,
pubmed-meshheading:17898992-Insulin Lispro,
pubmed-meshheading:17898992-Male,
pubmed-meshheading:17898992-Middle Aged,
pubmed-meshheading:17898992-Mitogens,
pubmed-meshheading:17898992-Mitosis,
pubmed-meshheading:17898992-Myocytes, Smooth Muscle,
pubmed-meshheading:17898992-Receptor, IGF Type 1,
pubmed-meshheading:17898992-Signal Transduction
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pubmed:year |
2007
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pubmed:articleTitle |
IGF-1 receptor signalling determines the mitogenic potency of insulin analogues in human smooth muscle cells and fibroblasts.
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pubmed:affiliation |
Institute of Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Auf'm Hennekamp 65, D-40225, Dusseldorf, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Evaluation Studies
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