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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-9-27
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pubmed:abstractText |
We evaluated the epidural administration of tezampanel, a non-N-methyl-d-aspartate receptor antagonist, in a rat model for postoperative pain. We sought to determine if this drug affects nociception when administered epidurally by testing its effects on responses to heat in normal rats. The effects of epidural tezampanel on pain-related behaviors in rats that underwent plantar incision were also studied.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1526-7598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
105
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1152-9, table of contents
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17898404-Analgesia, Epidural,
pubmed-meshheading:17898404-Analgesics, Opioid,
pubmed-meshheading:17898404-Animals,
pubmed-meshheading:17898404-Behavior, Animal,
pubmed-meshheading:17898404-Hot Temperature,
pubmed-meshheading:17898404-Injections, Subcutaneous,
pubmed-meshheading:17898404-Isoquinolines,
pubmed-meshheading:17898404-Male,
pubmed-meshheading:17898404-Morphine,
pubmed-meshheading:17898404-Pain, Postoperative,
pubmed-meshheading:17898404-Pain Measurement,
pubmed-meshheading:17898404-Pain Threshold,
pubmed-meshheading:17898404-Rats,
pubmed-meshheading:17898404-Rats, Sprague-Dawley,
pubmed-meshheading:17898404-Receptors, AMPA,
pubmed-meshheading:17898404-Receptors, Kainic Acid,
pubmed-meshheading:17898404-Tetrazoles,
pubmed-meshheading:17898404-Walking
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pubmed:year |
2007
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pubmed:articleTitle |
Epidural tezampanel, an AMPA/kainate receptor antagonist, produces postoperative analgesia in rats.
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pubmed:affiliation |
Department of Anesthesia, University of Iowa College of Medicine, Iowa City, IA 52242-1079, USA. tim-brennan@uiowa.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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