rdf:type |
|
lifeskim:mentions |
umls-concept:C0003364,
umls-concept:C0005823,
umls-concept:C0018787,
umls-concept:C0030705,
umls-concept:C0034656,
umls-concept:C0445204,
umls-concept:C0524727,
umls-concept:C0766108,
umls-concept:C1274040,
umls-concept:C1280500,
umls-concept:C1637379,
umls-concept:C1707887,
umls-concept:C2587213
|
pubmed:issue |
4
|
pubmed:dateCreated |
2007-9-27
|
pubmed:abstractText |
Clevidipine is an ultrashort-acting, third-generation IV dihydropyridine calcium channel blocker that exerts rapid and titratable arterial blood pressure reduction, with fast termination of effect due to metabolism by blood and tissue esterases. As an arterial-selective vasodilator, clevidipine reduces peripheral vascular resistance directly, without dilating the venous capacitance bed. In this randomized, double-blind, placebo-controlled multicenter trial we evaluated the efficacy and tolerability of clevidipine in treating preoperative hypertension.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1526-7598
|
pubmed:author |
|
pubmed:issnType |
Electronic
|
pubmed:volume |
105
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
918-25, table of contents
|
pubmed:meshHeading |
pubmed-meshheading:17898366-Aged,
pubmed-meshheading:17898366-Antihypertensive Agents,
pubmed-meshheading:17898366-Blood Pressure,
pubmed-meshheading:17898366-Calcium Channel Blockers,
pubmed-meshheading:17898366-Cardiac Surgical Procedures,
pubmed-meshheading:17898366-Double-Blind Method,
pubmed-meshheading:17898366-Female,
pubmed-meshheading:17898366-Humans,
pubmed-meshheading:17898366-Hypertension,
pubmed-meshheading:17898366-Male,
pubmed-meshheading:17898366-Middle Aged,
pubmed-meshheading:17898366-Preoperative Care,
pubmed-meshheading:17898366-Pyridines,
pubmed-meshheading:17898366-Treatment Outcome,
pubmed-meshheading:17898366-Vasodilator Agents
|
pubmed:year |
2007
|
pubmed:articleTitle |
Clevidipine effectively and rapidly controls blood pressure preoperatively in cardiac surgery patients: the results of the randomized, placebo-controlled efficacy study of clevidipine assessing its preoperative antihypertensive effect in cardiac surgery-1.
|
pubmed:affiliation |
Cardiothoracic Anesthesiology and Critical Care, Emory University Hospital, Atlanta, Georgia 30322, USA. jerrold.levy@emoryhealthcare.org
|
pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase III
|