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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1992-3-25
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pubmed:abstractText |
Three polymorphic sites of the apolipoprotein B gene - the insertion/deletion signal peptide, XbaI and EcoRI sites - were examined in a sample of 107 healthy men and in 46 men with evidence of coronary heart disease selected from a large population survey of South Asians aged 40-69 in London, U.K. There were no significant differences in allele frequencies between cases and controls. Frequencies of the ins (insertion) and X- (absence of XbaI cutting site) alleles were higher in South Asians than in Europeans studied previously (South Asians versus Europeans ins: 0.80 vs. 0.68, P less than 0.025; X-: 0.71 vs. 0.47-0.56, P less than 0.001). The del allele was associated with higher levels of total cholesterol (P less than 0.05) and the X+ allele with lower levels of HDL cholesterol (P less than 0.05), and thus both polymorphisms were associated with differences in the ratio of HDL cholesterol to total cholesterol (ins/del, P less than 0.01; XbaI, P less than 0.001). Mean waist-hip girth ratio was lower in the 10 men homozygous for the X+ allele than in the 42 men with X-/X+ and 55 men with X-/X- genotypes; the means (+/- SEM) were 0.92 +/- 0.02, 0.97 +/- 0.01 and 0.96 +/- 0.01 respectively (P = 0.03). These data suggest that genetic variation in linkage disequilibrium with the XbaI and ins/del polymorphisms of the apo B gene contributes to the determination of total cholesterol and HDL cholesterol levels and possibly to obesity in South Asians.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9150
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
267-75
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1789809-Adult,
pubmed-meshheading:1789809-Aged,
pubmed-meshheading:1789809-Alleles,
pubmed-meshheading:1789809-Apolipoproteins B,
pubmed-meshheading:1789809-Base Sequence,
pubmed-meshheading:1789809-Cholesterol,
pubmed-meshheading:1789809-Cholesterol, HDL,
pubmed-meshheading:1789809-Coronary Disease,
pubmed-meshheading:1789809-England,
pubmed-meshheading:1789809-Genotype,
pubmed-meshheading:1789809-Humans,
pubmed-meshheading:1789809-India,
pubmed-meshheading:1789809-Lipids,
pubmed-meshheading:1789809-Male,
pubmed-meshheading:1789809-Middle Aged,
pubmed-meshheading:1789809-Molecular Sequence Data,
pubmed-meshheading:1789809-Polymorphism, Genetic
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pubmed:year |
1991
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pubmed:articleTitle |
Apolipoprotein B gene polymorphisms are associated with lipid levels in men of South Asian descent.
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pubmed:affiliation |
Arterial Diseases Research Group, Charing Cross Sunley Research Centre, Hammersmith, London, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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