Linked Life Data

17897402

Source:http://linkedlifedata.com/resource/pubmed/id/17897402

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2007-9-27
pubmed:abstractText
In mammals, the suprachiasmatic nucleus (SCN) of the hypothalamus is the master circadian pacemaker. The SCN controls daily rhythms and synchronizes the organism to its environment and especially to photic signals. Photic signals via the retinohypothalamic tract reach the ventral part of the SCN, where the majority of calbindin-containing neurons are located. Calbindin cells seem important for the control of circadian rhythmicity. As ageing leads to marked changes in the expression of circadian rhythms, we investigated in the mouse lemur, a nocturnal primate, age-related changes in the oscillation of calbindin protein expression in SCN neurons. We used immunohistochemistry and quantitative analysis of calbindin expression in the SCN of adult and aged mouse lemurs. In this primate, a dense cluster of calbindin-positive neurons was found in the ventral part of the SCN. In adult animals, calbindin-positive SCN neurons did not exhibit daily rhythms in their number or intensity, but exhibited significant daily variations in the percentage of cells with a calbindin-positive nucleus, characterized by high values during the daytime and low values during the night. Immunoreactive intensity peaked in the middle of the daytime. Calbindin expression in the nuclei of calbindin cells in the SCN tends to be modified by ageing. The amplitude of daily variation in calbindin expression was damped, with a lower immunointensity during the daytime and a delayed decrease during the night. These changes may affect the ability of the SCN to transmit rhythmic information to other SCN cells and thereby modify the synchronization of the different cell populations in the SCN.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0953-816X
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2025-32
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Calbindin D28K protein cells in a primate suprachiasmatic nucleus: localization, daily rhythm and age-related changes.
pubmed:affiliation
Adaptive Mechanisms and Evolution, CNRS-MNHN UMR 7179, Brunoy, France. florence.cayetanot@univ-cezanne.fr
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't