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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-9-27
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pubmed:abstractText |
The presence of the 14-bp insertion polymorphism of the human leucocyte antigen (HLA)-G gene (HLA-G) promotes immune tolerance through increased synthesis of HLA-G molecules. We investigated this polymorphism in a large cohort of 53 thalassaemia patients transplanted from an unrelated donor. Sixteen patients (30.2%) homozygous for the 14-bp deletion had a higher risk of developing acute graft-versus-host disease (aGvHD) than patients homozygous for the 14-bp insertion (-14-bp/-14-bp vs +14-bp/+14-bp: Relative Risk = 15.0; 95% confidence interval 1.59-141.24; P = 0.008). Therefore, the 14-bp polymorphism could be an important predictive factor for aGvHD following bone marrow transplantation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0007-1048
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pubmed:author |
pubmed-author:AlbaFrancescoF,
pubmed-author:BernardoMaria EsterME,
pubmed-author:CaocciGiovanniG,
pubmed-author:CarcassiCarloC,
pubmed-author:Di Cesare-MerloneAlessandraA,
pubmed-author:La NasaGiorgioG,
pubmed-author:LisiniDanielaD,
pubmed-author:LitteraRobertoR,
pubmed-author:LocatelliFrancoF,
pubmed-author:NesciSoniaS,
pubmed-author:OrrùSandroS,
pubmed-author:PirasEugeniaE,
pubmed-author:SatsN VNV,
pubmed-author:VaccaAdrianaA
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pubmed:issnType |
Print
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
284-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17897304-Adolescent,
pubmed-meshheading:17897304-Adult,
pubmed-meshheading:17897304-Bone Marrow Transplantation,
pubmed-meshheading:17897304-Child,
pubmed-meshheading:17897304-Child, Preschool,
pubmed-meshheading:17897304-Female,
pubmed-meshheading:17897304-Gene Deletion,
pubmed-meshheading:17897304-Genes, MHC Class I,
pubmed-meshheading:17897304-Genetic Testing,
pubmed-meshheading:17897304-Graft vs Host Disease,
pubmed-meshheading:17897304-Humans,
pubmed-meshheading:17897304-Male,
pubmed-meshheading:17897304-Polymorphism, Genetic,
pubmed-meshheading:17897304-Risk Assessment,
pubmed-meshheading:17897304-Thalassemia,
pubmed-meshheading:17897304-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
The human leucocyte antigen-G 14-basepair polymorphism correlates with graft-versus-host disease in unrelated bone marrow transplantation for thalassaemia.
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pubmed:affiliation |
Cattedra di Ematologia, Centro Trapianti Midollo osseo, Ospedale R. Binaghi, Dipartimento di Scienze Mediche Internistiche, University of Cagliari, Cagliari, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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