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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2008-7-16
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pubmed:abstractText |
Oestrogen receptor alpha (ER alpha) is traditionally measured on all breast tumour specimens to identify those patients more likely to respond to anti-oestrogens. Progesterone receptor (PR) status has contributed useful information in defining more responsive subgroups. PR negativity may be a marker for increased signalling through growth factor receptor tyrosine kinase pathways. Progesterone acts through two PRs, PRA and PRB. PRB, the functionally active PR, can be silenced by promoter hypermethylation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0167-6806
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pubmed:author |
pubmed-author:ChungWen YWY,
pubmed-author:CookeFiachraF,
pubmed-author:DervanPeter APA,
pubmed-author:FitzpatrickPatriciaP,
pubmed-author:FlynnBarbaraB,
pubmed-author:FoxEdwardE,
pubmed-author:GallagherEmmaE,
pubmed-author:HarrisonMicheleM,
pubmed-author:KerinMichael JMJ,
pubmed-author:Mc CormackOrlaO,
pubmed-author:McCannAmandaA,
pubmed-author:McGoldrickAloysiusA
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pubmed:issnType |
Print
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pubmed:volume |
111
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
45-53
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17896177-Base Sequence,
pubmed-meshheading:17896177-Breast Neoplasms,
pubmed-meshheading:17896177-DNA Methylation,
pubmed-meshheading:17896177-Estrogen Receptor alpha,
pubmed-meshheading:17896177-Female,
pubmed-meshheading:17896177-Humans,
pubmed-meshheading:17896177-Immunohistochemistry,
pubmed-meshheading:17896177-Prognosis,
pubmed-meshheading:17896177-Promoter Regions, Genetic,
pubmed-meshheading:17896177-RNA, Messenger,
pubmed-meshheading:17896177-Receptors, Progesterone,
pubmed-meshheading:17896177-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17896177-Tumor Markers, Biological
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pubmed:year |
2008
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pubmed:articleTitle |
Progesterone receptor B (PRB) promoter hypermethylation in sporadic breast cancer: progesterone receptor B hypermethylation in breast cancer.
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pubmed:affiliation |
The Adelaide and Meath Hospital, Dublin Incorporating the National Childrens Hospital, Tallaght, Dublin, 24, Ireland. omccormack@rcsi.ie
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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