| pubmed-article:17896076 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17896076 | lifeskim:mentions | umls-concept:C0085209 | lld:lifeskim |
| pubmed-article:17896076 | lifeskim:mentions | umls-concept:C0449438 | lld:lifeskim |
| pubmed-article:17896076 | lifeskim:mentions | umls-concept:C0205182 | lld:lifeskim |
| pubmed-article:17896076 | lifeskim:mentions | umls-concept:C2936546 | lld:lifeskim |
| pubmed-article:17896076 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:17896076 | lifeskim:mentions | umls-concept:C0032356 | lld:lifeskim |
| pubmed-article:17896076 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:17896076 | pubmed:dateCreated | 2008-1-21 | lld:pubmed |
| pubmed-article:17896076 | pubmed:abstractText | The aim of this study was to analyze molecular features of protease-resistant prion protein (PrP(res)) in Western blots of BSE cases diagnosed in Poland with respect to a possible atypical status. Confirmed cases were analyzed by Western blotting with several monoclonal antibodies directed at N-terminal and core epitopes of prion protein (PrP). Most cases showed the classical glycoprofile characterized by the dominance of the di- over the monoglycosylated PrP(res) band, yielding di-/mono- ratios well above 2 and by reactivity with antibodies having their epitopes in bovine PrP region 110-242 (C-type cases). Surprisingly, seven cases of BSE were atypical. Six were classified as L-type based on a slightly lower molecular mass (M(r)) of the non- glycosylated band with respect to C-types and a conspicuously low di-/mono- ratio of glycosylated PrP(res) bands approaching unity. One case was classified as H-type because of a higher M(r) of PrP(res) bands on the blot when compared with C-type cases. A characteristic epitope of H-type PrP(res) occurred in the 101-110 region of PrP for which only antibody 12B2 had a sufficient affinity. The occurrence of atypical cases only in animals 9 years of age and older raises questions about the mechanisms of prion diseases and the origin of BSE. | lld:pubmed |
| pubmed-article:17896076 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17896076 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17896076 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17896076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17896076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17896076 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17896076 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17896076 | pubmed:issn | 0304-8608 | lld:pubmed |
| pubmed-article:17896076 | pubmed:author | pubmed-author:JacobiJ EJE | lld:pubmed |
| pubmed-article:17896076 | pubmed:author | pubmed-author:PolakM PMP | lld:pubmed |
| pubmed-article:17896076 | pubmed:author | pubmed-author:ZmudzinskiJ... | lld:pubmed |
| pubmed-article:17896076 | pubmed:author | pubmed-author:LangeveldJ... | lld:pubmed |
| pubmed-article:17896076 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17896076 | pubmed:volume | 153 | lld:pubmed |
| pubmed-article:17896076 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17896076 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17896076 | pubmed:pagination | 69-79 | lld:pubmed |
| pubmed-article:17896076 | pubmed:meshHeading | pubmed-meshheading:17896076... | lld:pubmed |
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| pubmed-article:17896076 | pubmed:meshHeading | pubmed-meshheading:17896076... | lld:pubmed |
| pubmed-article:17896076 | pubmed:meshHeading | pubmed-meshheading:17896076... | lld:pubmed |
| pubmed-article:17896076 | pubmed:meshHeading | pubmed-meshheading:17896076... | lld:pubmed |
| pubmed-article:17896076 | pubmed:meshHeading | pubmed-meshheading:17896076... | lld:pubmed |
| pubmed-article:17896076 | pubmed:meshHeading | pubmed-meshheading:17896076... | lld:pubmed |
| pubmed-article:17896076 | pubmed:year | 2008 | lld:pubmed |
| pubmed-article:17896076 | pubmed:articleTitle | Atypical status of bovine spongiform encephalopathy in Poland: a molecular typing study. | lld:pubmed |
| pubmed-article:17896076 | pubmed:affiliation | National Veterinary Research Institute, Pulawy, Poland. ppolak@piwet.pulawy.pl | lld:pubmed |
| pubmed-article:17896076 | pubmed:publicationType | Journal Article | lld:pubmed |
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