Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
40
pubmed:dateCreated
2007-10-3
pubmed:abstractText
The gastrointestinal tract is constantly challenged by foreign antigens and commensal bacteria but nonetheless is able to maintain a state of immunological quiescence. Recent advances have highlighted the importance of active suppression by regulatory lymphocytes and immunosuppressive cytokines in controlling mucosal immunity. Failures of these mechanisms contribute to the development of inflammatory bowel disease, but how these regulatory networks are established remains unclear. Here, we demonstrate key roles for alphav integrins in regulation of mucosal immunity. We report that deletion of alphav in the immune system causes severe colitis, autoimmunity, and cancer. Mice lacking immune cell alphav have fewer regulatory T (Treg) cells in the colon and corresponding increases in activated T cells and T cell cytokine production, leading to colitis. Using conditional gene targeting, we demonstrate that this is specifically attributable to loss of alphav from myeloid cells. Furthermore, we show that gut-associated macrophages and dendritic cells fail both to remove apoptotic cells efficiently and to induce Treg cells. Our results identify a vital role for myeloid alphav integrins in generating mucosal Treg cells and emphasize the importance of antigen-presenting cells in establishing immune tolerance.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-10025398, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-10621974, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-10629031, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-10662789, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-10714683, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-11048729, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-11161575, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-11353516, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-11823490, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-11911830, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-12297042, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-12461569, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-12515818, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-12658273, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-15039759, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-15155946, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-15789058, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-15962005, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-16216886, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-16251442, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-1688647, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-16951368, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-17481928, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-7903159, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-8450225, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-8666675, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-9295024, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-9763615, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-9827803, http://linkedlifedata.com/resource/pubmed/commentcorrection/17895374-9916135
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
2
pubmed:volume
104
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
15823-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Ulcerative colitis and autoimmunity induced by loss of myeloid alphav integrins.
pubmed:affiliation
Medical Research Council/University of Edinburgh Centre for Inflammation Research, The Queen's Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom. adamlh@mit.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural