Source:http://linkedlifedata.com/resource/pubmed/id/17893676
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2007-10-22
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pubmed:abstractText |
Interleukin 7 is essential for the survival of naive T lymphocytes. Despite its importance, its cellular source in the periphery remains poorly defined. Here we report a critical function for lymph node access in T cell homeostasis and identify T zone fibroblastic reticular cells in these organs as the main source of interleukin 7. In vitro, T zone fibroblastic reticular cells were able to prevent the death of naive T lymphocytes but not of B lymphocytes by secreting interleukin 7 and the CCR7 ligand CCL19. Using gene-targeted mice, we demonstrate a nonredundant function for CCL19 in T cell homeostasis. Our data suggest that lymph nodes and T zone fibroblastic reticular cells have a key function in naive CD4(+) and CD8(+) T cell homeostasis by providing a limited reservoir of survival factors.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1529-2908
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1255-65
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pubmed:meshHeading |
pubmed-meshheading:17893676-Adoptive Transfer,
pubmed-meshheading:17893676-Animals,
pubmed-meshheading:17893676-Cell Survival,
pubmed-meshheading:17893676-Chemokine CCL19,
pubmed-meshheading:17893676-Fibroblasts,
pubmed-meshheading:17893676-Flow Cytometry,
pubmed-meshheading:17893676-Fluorescent Antibody Technique,
pubmed-meshheading:17893676-Gene Expression,
pubmed-meshheading:17893676-Homeostasis,
pubmed-meshheading:17893676-In Situ Hybridization,
pubmed-meshheading:17893676-Interleukin-7,
pubmed-meshheading:17893676-Lymph Nodes,
pubmed-meshheading:17893676-Mice,
pubmed-meshheading:17893676-Mice, Inbred C57BL,
pubmed-meshheading:17893676-RNA, Messenger,
pubmed-meshheading:17893676-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17893676-T-Lymphocytes
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pubmed:year |
2007
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pubmed:articleTitle |
Fibroblastic reticular cells in lymph nodes regulate the homeostasis of naive T cells.
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pubmed:affiliation |
Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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