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rdf:type |
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lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0001792,
umls-concept:C0006104,
umls-concept:C0007776,
umls-concept:C0022655,
umls-concept:C0023317,
umls-concept:C0026045,
umls-concept:C0041904,
umls-concept:C0162493,
umls-concept:C0206745,
umls-concept:C1264633,
umls-concept:C1720655,
umls-concept:C1947974,
umls-concept:C2700455
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pubmed:dateCreated |
2007-9-25
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pubmed:abstractText |
Alpha-crystallin is expressed at high levels in the lens in a complex of alphaA- and alphaB-crystallin subunits in 3:1 molar ratios, and is known to maintain the solubility of unpolymerized tubulin and enhance the resistance of microtubules to depolymerization, but its effect on proteins classically associated with microtubule stability (microtubule associated proteins) in the lens is unknown. In the present study we examined the expression of the brain microtubule associated protein tau in lenses of alpha-crystallin gene knockout mice.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1090-0535
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1589-600
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17893660-Aging,
pubmed-meshheading:17893660-Animals,
pubmed-meshheading:17893660-Brain,
pubmed-meshheading:17893660-Immunoblotting,
pubmed-meshheading:17893660-Immunohistochemistry,
pubmed-meshheading:17893660-Lens Cortex, Crystalline,
pubmed-meshheading:17893660-Mice,
pubmed-meshheading:17893660-Mice, Knockout,
pubmed-meshheading:17893660-Microscopy, Immunoelectron,
pubmed-meshheading:17893660-Phosphorylation,
pubmed-meshheading:17893660-RNA, Messenger,
pubmed-meshheading:17893660-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17893660-Up-Regulation,
pubmed-meshheading:17893660-alpha-Crystallin A Chain,
pubmed-meshheading:17893660-alpha-Crystallin B Chain,
pubmed-meshheading:17893660-tau Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Up-regulation of tau, a brain microtubule-associated protein, in lens cortical fractions of aged alphaA-, alphaB-, and alphaA/B-crystallin knockout mice.
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pubmed:affiliation |
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO 63110, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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