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rdf:type |
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lifeskim:mentions |
umls-concept:C0018131,
umls-concept:C0023693,
umls-concept:C0037083,
umls-concept:C0332206,
umls-concept:C0443252,
umls-concept:C1332709,
umls-concept:C1420808,
umls-concept:C1420817,
umls-concept:C1527148,
umls-concept:C1704410,
umls-concept:C1710082
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pubmed:issue |
6
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pubmed:dateCreated |
2007-9-25
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pubmed:abstractText |
Previous studies have shown that blockade of LIGHT, a T-cell costimulatory molecule belonging to the tumor necrosis factor (TNF) superfamily, by soluble lymphotoxin beta receptor-Ig (LTbetaR-Ig) inhibited the development of graft-versus-host disease. The cardiac allografts were significantly prolonged in LIGHT deficient mice. No data are yet available regarding the role of the LIGHT/HVEM pathway in more stringent fully allogeneic models such as skin and islet transplantation models.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoconjugates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulins,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/abatacept
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0041-1337
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pubmed:author |
pubmed-author:BradyW EWE,
pubmed-author:DaiJianxinJ,
pubmed-author:FanKexingK,
pubmed-author:GuoYajunY,
pubmed-author:HouShengS,
pubmed-author:KouGengG,
pubmed-author:QianWeizhuW,
pubmed-author:WangHaoH,
pubmed-author:WeiHuafengH,
pubmed-author:ZhangYanyunY,
pubmed-author:ZhouQianQ,
pubmed-author:ZhuTongyuT
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pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
746-54
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pubmed:meshHeading |
pubmed-meshheading:17893608-Animals,
pubmed-meshheading:17893608-Antibodies, Monoclonal,
pubmed-meshheading:17893608-Antigens, CD28,
pubmed-meshheading:17893608-Antigens, CD80,
pubmed-meshheading:17893608-Graft Survival,
pubmed-meshheading:17893608-Immunoconjugates,
pubmed-meshheading:17893608-Immunoglobulins,
pubmed-meshheading:17893608-Immunosuppressive Agents,
pubmed-meshheading:17893608-Islets of Langerhans Transplantation,
pubmed-meshheading:17893608-Mice,
pubmed-meshheading:17893608-Mice, Inbred BALB C,
pubmed-meshheading:17893608-Phenotype,
pubmed-meshheading:17893608-Receptors, Tumor Necrosis Factor, Member 14,
pubmed-meshheading:17893608-T-Lymphocytes, Regulatory,
pubmed-meshheading:17893608-Transplantation, Homologous,
pubmed-meshheading:17893608-Transplantation Tolerance
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pubmed:year |
2007
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pubmed:articleTitle |
Blockade of LIGHT/HVEM and B7/CD28 signaling facilitates long-term islet graft survival with development of allospecific tolerance.
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pubmed:affiliation |
International Joint Cancer Institute, The Second Military Medical University, Shanghai, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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