17893434

Source:http://linkedlifedata.com/resource/pubmed/id/17893434

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0002085, umls-concept:C0018591, umls-concept:C0019721, umls-concept:C0023418, umls-concept:C0030705, umls-concept:C0439603, umls-concept:C0456387, umls-concept:C1553355
pubmed:issue	3
pubmed:dateCreated	2007-9-25
pubmed:abstractText	Previous studies demonstrated significant differences in a number of HLA allele frequencies in leukemia patients and normal subjects. In this study, we have analyzed HLA class II alleles and haplotypes in 110 leukemia patients (60 acute myelogenous leukemia "AML", 50 chronic myelogenous leukemia"CML") and 180 unrelated normal subjects. Blood samples were collected from all of the patients and control subjects. DNA was extracted by salting out method and HLA typing was performed using PCR-SSP method. Significant positive association with AML was obtained for HLA-DRB111allele (35% vs. 24.7%, P=0.033). Two alleles including HLA-DRB4 and -DQB10303 were significantly less frequent in AML patients than in controls. HLA-DQB10303 allele was never observed in CML patients compared with allele frequency in controls (4.2%). According to haplotype analysis, HLA-DRB10101/DQA10104/-DQB10501 frequencies were significantly higher and -DRB116/-DQA101021/-DQB10501 frequencies were significantly lower in CML patients than in controls. In conclusion it is suggested that HLA-DRB116 allele and HLA-DRB115/-DQA10103/-DQB106011 and -DRB116/-DQA101021/-DQB10501 haplotypes predispose individuals to AML and HLA-DRB4 allele predispose to CML. Future studies are needed to confirm these results and establish the role of these associations in AML and CML.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/101146178
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II
pubmed:status	MEDLINE
pubmed:month	Sep
pubmed:issn	1735-1502
pubmed:author	pubmed-author:AlimoghadamKamranK, pubmed-author:AmirzargarAliakbarA, pubmed-author:DianatSaiedS, pubmed-author:KhosraviFaridehF, pubmed-author:NicknamMohammad HosseinMH, pubmed-author:NikbinBehrouzB, pubmed-author:SarafnejadAbdolfatahA, pubmed-author:SolgiGhasemG
pubmed:issnType	Print
pubmed:volume	6
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	137-42
pubmed:meshHeading	pubmed-meshheading:17893434-Alleles, pubmed-meshheading:17893434-Haplotypes, pubmed-meshheading:17893434-Histocompatibility Antigens Class II, pubmed-meshheading:17893434-Humans, pubmed-meshheading:17893434-Iran, pubmed-meshheading:17893434-Leukemia, Myeloid
pubmed:year	2007
pubmed:articleTitle	HLA class II allele and haplotype frequencies in Iranian patients with leukemia.
pubmed:affiliation	Molecular Immunology Research Center, Department of Immunology, Medical School, Medical Sciences, University of Tehran, Tehran, Iran.
pubmed:publicationType	Journal Article, Research Support, Non-U.S. Gov't