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rdf:type |
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lifeskim:mentions |
umls-concept:C0001455,
umls-concept:C0001492,
umls-concept:C0007412,
umls-concept:C0038435,
umls-concept:C0178702,
umls-concept:C0205191,
umls-concept:C0332307,
umls-concept:C0332453,
umls-concept:C0442805,
umls-concept:C1710082,
umls-concept:C2349975
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pubmed:issue |
16
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pubmed:dateCreated |
2007-10-16
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pubmed:abstractText |
Desensitization of the cyclic adenosine monophosphate signal protects cardiac myocytes against catecholamine stress, thus preventing the development of apoptosis. Molecular mechanisms of desensitization have been well studied at the level of adrenergic receptors but less so at the level of the effector enzyme, adenylyl cyclase (AC).
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Monophosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Adenylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Adrbk1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Catecholamines,
http://linkedlifedata.com/resource/pubmed/chemical/G-Protein-Coupled Receptor Kinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-akt,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/adenylyl cyclase 6,
http://linkedlifedata.com/resource/pubmed/chemical/adenylyl cyclase type V
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BaiYunzheY,
pubmed-author:GaoShuminS,
pubmed-author:GhoshKaushikK,
pubmed-author:IshikawaYoshihiroY,
pubmed-author:IwatsuboKousakuK,
pubmed-author:KawabeJun-ichiJ,
pubmed-author:KurotaniReikoR,
pubmed-author:OkumuraSatoshiS,
pubmed-author:UlucanCoskunC,
pubmed-author:VatnerDorothy EDE,
pubmed-author:VatnerStephen FSF,
pubmed-author:YuanZengrongZ
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pubmed:issnType |
Electronic
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pubmed:day |
16
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pubmed:volume |
116
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1776-83
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pubmed:dateRevised |
2010-10-13
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pubmed:meshHeading |
pubmed-meshheading:17893275-Adenosine Monophosphate,
pubmed-meshheading:17893275-Adenylate Cyclase,
pubmed-meshheading:17893275-Adrenergic beta-Agonists,
pubmed-meshheading:17893275-Animals,
pubmed-meshheading:17893275-Apoptosis,
pubmed-meshheading:17893275-Catecholamines,
pubmed-meshheading:17893275-Chronic Disease,
pubmed-meshheading:17893275-Down-Regulation,
pubmed-meshheading:17893275-G-Protein-Coupled Receptor Kinase 2,
pubmed-meshheading:17893275-Heart Failure,
pubmed-meshheading:17893275-Isoenzymes,
pubmed-meshheading:17893275-Isoproterenol,
pubmed-meshheading:17893275-Male,
pubmed-meshheading:17893275-Mice,
pubmed-meshheading:17893275-Mice, Knockout,
pubmed-meshheading:17893275-Myocytes, Cardiac,
pubmed-meshheading:17893275-Proto-Oncogene Proteins c-akt,
pubmed-meshheading:17893275-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:17893275-Signal Transduction,
pubmed-meshheading:17893275-Stress, Physiological
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pubmed:year |
2007
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pubmed:articleTitle |
Disruption of type 5 adenylyl cyclase enhances desensitization of cyclic adenosine monophosphate signal and increases Akt signal with chronic catecholamine stress.
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pubmed:affiliation |
Cardiovascular Research Institute, Yokohama City University Graduate School of Medicine, Yokohama, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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