|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2007-10-16
|
|
pubmed:abstractText |
The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the possibility that nitrite contributes to hypoxic vasodilation and to the bioactivity of nitroglycerin and mediates the cardiovascular protective effects of nitrate in the Mediterranean diet. However, important questions of potency, kinetics, mechanism of action, and possible induction of tolerance remain unanswered.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
1524-4539
|
|
pubmed:author |
pubmed-author:CannonRichard ORO3rd,
pubmed-author:DejamAndréA,
pubmed-author:GladwinMark TMT,
pubmed-author:GrimesGeorgeG,
pubmed-author:HonYuen YiYY,
pubmed-author:HunterChristian JCJ,
pubmed-author:OldfieldEdward HEH,
pubmed-author:PartoviKristineK,
pubmed-author:PelletierMildred MMM,
pubmed-author:PlutaRyszard MRM,
pubmed-author:SchechterAlan NAN,
pubmed-author:TremontiCaroleC
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
16
|
|
pubmed:volume |
116
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1821-31
|
|
pubmed:meshHeading |
pubmed-meshheading:17893272-Adult,
pubmed-meshheading:17893272-Animals,
pubmed-meshheading:17893272-Antioxidants,
pubmed-meshheading:17893272-Ascorbic Acid,
pubmed-meshheading:17893272-Drug Tolerance,
pubmed-meshheading:17893272-Endocrine System,
pubmed-meshheading:17893272-Endothelium, Vascular,
pubmed-meshheading:17893272-Enzyme Inhibitors,
pubmed-meshheading:17893272-Female,
pubmed-meshheading:17893272-Hemoglobins,
pubmed-meshheading:17893272-Humans,
pubmed-meshheading:17893272-Infusions, Intra-Arterial,
pubmed-meshheading:17893272-Macaca fascicularis,
pubmed-meshheading:17893272-Male,
pubmed-meshheading:17893272-Nitric Oxide,
pubmed-meshheading:17893272-Oxidation-Reduction,
pubmed-meshheading:17893272-Oxypurinol,
pubmed-meshheading:17893272-Regional Blood Flow,
pubmed-meshheading:17893272-Sodium Nitrite,
pubmed-meshheading:17893272-Vasodilation,
pubmed-meshheading:17893272-Vasodilator Agents,
pubmed-meshheading:17893272-Xanthine Oxidase
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation.
|
|
pubmed:affiliation |
Molecular Medicine Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
|
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, N.I.H., Intramural
|
