Linked Life Data

17891664

Source:http://linkedlifedata.com/resource/pubmed/id/17891664

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pubmed-article:17891664pubmed:abstractTextAn assay in which groups perform at both similar and significantly different levels within the same test session may have experimental advantages both in understanding underlying behavioral-cognitive processes and in helping to resolve neuroimaging issues regarding functional significance vs. performance confounds. Here we report behavioral data from a response inhibition (Go/No-Go) task with two levels of No-Go difficulty (easy, hard). The sample included individuals with current cocaine dependence (N=18) and controls (N=15). Using signal detection methodology (d' and Beta), significant main effects were observed for group and trial type on d'. Post-hoc analyses revealed the cocaine-dependent individuals performed significantly worse than controls on difficult, but not easy, trials. Differences on d' but not Beta, and slower reaction times in cocaine subjects, suggest that response inhibition deficits were related to disruption in visual information processing rather than inhibition of motor activity.lld:pubmed
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pubmed-article:17891664pubmed:authorpubmed-author:LaneScott DSDlld:pubmed
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pubmed-article:17891664pubmed:pagination717-26lld:pubmed
pubmed-article:17891664pubmed:dateRevised2008-11-21lld:pubmed
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pubmed-article:17891664pubmed:articleTitlePerformance of cocaine dependent individuals and controls on a response inhibition task with varying levels of difficulty.lld:pubmed
pubmed-article:17891664pubmed:affiliationDepartment of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. scott.d.lane@uth.tmc.edulld:pubmed
pubmed-article:17891664pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:17891664pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed
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