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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2007-9-24
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pubmed:abstractText |
The molecular mechanisms that maintain the equilibrium of odontoblast progenitor cells in dental pulp are unknown. Here we tested whether homeostasis in dental pulp is modulated by Twist-1, a nuclear protein that partners with Runx2 during osteoblast differentiation. Our analysis of Twist-1(+/-) mice revealed phenotypic changes that involved an earlier onset of dentin matrix formation, increased alkaline phosphatase activity, and pulp stones within the pulp. RT-PCR analyses revealed Twist-1 expression in several adult organs, including pulp. Decreased levels of Twist-1 led to higher levels of type I collagen and Dspp gene expression in perivascular cells associated with the pulp stones. In mice heterozygous for both Twist-1 and Runx2 inactivation, the phenotype of pulp stones appeared completely rescued. These findings suggest that Twist-1 plays a key role in restraining odontoblast differentiation, thus maintaining homeostasis in dental pulp. Furthermore, Twist-1 functions in dental pulp are dependent on its interaction with Runx2.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Core Binding Factor Alpha 1 Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Extracellular Matrix Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors,
http://linkedlifedata.com/resource/pubmed/chemical/Runx2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Twist Transcription Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Twist1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/dentin sialophosphoprotein
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-0345
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
951-5
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17890670-Animals,
pubmed-meshheading:17890670-Cell Differentiation,
pubmed-meshheading:17890670-Cells, Cultured,
pubmed-meshheading:17890670-Collagen Type I,
pubmed-meshheading:17890670-Core Binding Factor Alpha 1 Subunit,
pubmed-meshheading:17890670-Dental Pulp,
pubmed-meshheading:17890670-Dental Pulp Calcification,
pubmed-meshheading:17890670-Extracellular Matrix Proteins,
pubmed-meshheading:17890670-Homeostasis,
pubmed-meshheading:17890670-Mice,
pubmed-meshheading:17890670-Mice, Mutant Strains,
pubmed-meshheading:17890670-Nuclear Proteins,
pubmed-meshheading:17890670-Odontoblasts,
pubmed-meshheading:17890670-Phosphoproteins,
pubmed-meshheading:17890670-Protein Precursors,
pubmed-meshheading:17890670-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17890670-Sialoglycoproteins,
pubmed-meshheading:17890670-Twist Transcription Factor
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pubmed:year |
2007
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pubmed:articleTitle |
A novel role for Twist-1 in pulp homeostasis.
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pubmed:affiliation |
Department of Biomedical Sciences, Texas A&M University Health Science Center, Baylor College of Dentistry, 3302 Gaston Avenue, Dallas, TX 75246, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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