Linked Life Data

17890267

Source:http://linkedlifedata.com/resource/pubmed/id/17890267

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2007-9-24
pubmed:abstractText
In the last decade the incidence of BK virus infection has increased in renal transplant recipients and become an important factor negatively influencing graft outcome. BK virus infection cannot be attributed to a single immunosuppressive agent or regimen. The risk of BKV infection is related to the overall load of immunosuppression, which is determined not only by immunosuppressive drugs but also by the humoral and cellular immunity of the recipient. Reduction in immunosuppression at this time appears to be the best available approach to the treatment of established BKVN. Assays are lacking that are able to measure the degree of immunosuppression in a given patient at a given time after transplantation. The balance between a sufficient yet nontoxic immunosuppressive regimen remains a major problem in preventing complications such as BK virus nephropathy. This article will focus on the influence of immunosuppressive medication on the development of BKVN. The role of other aspects such as viral virulence, humoral and cellular immunity or renal specificity will be shortly discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0931-0509
pubmed:author
pubmed:issnType
Print
pubmed:volume
22 Suppl 8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
viii66-viii71
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The influence of immunosuppression on the development of BK virus nephropathy-- does it matter?
pubmed:affiliation
Nierenzentrum Heidelberg, Department of Nephrology/University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg. beimler@gmx.de
pubmed:publicationType
Journal Article, Review