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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-11-23
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pubmed:abstractText |
The majority of researchers investigating hyperpolarized gas MRI as a candidate functional lung imaging modality have used (3)He as their imaging agent of choice rather than (129)Xe. This preference has been predominantly due to, (3)He providing stronger signals due to higher levels of polarization and higher gyromagnetic ratio, as well as its being easily available to more researchers due to availability of polarizers (USA) or ease of gas transport (Europe). Most researchers agree, however, that hyperpolarized (129)Xe will ultimately emerge as the imaging agent of choice due to its unlimited supply in nature and its falling cost. Our recent polarizer technology delivers vast improvements in hyperpolarized (129)Xe output. Using this polarizer, we have demonstrated the unique property of xenon to measure alveolar surface area noninvasively. In this article, we describe our human protocols and their safety, and our results for the measurement of the partial pressure of pulmonary oxygen (pO(2)) by observation of (129)Xe signal decay. We note that the measurement of pO(2) by observation of (129)Xe signal decay is more complex than that for (3)He because of an additional signal loss mechanism due to interphase diffusion of (129)Xe from alveolar gas spaces to septal tissue. This results in measurements of an equivalent pO(2) that accounts for both traditional T(1) decay from pO(2) and that from interphase diffusion. We also provide an update on new technological advancements that form the foundation for an improved compact design polarizer as well as improvements that provide another order-of-magnitude scale-up in xenon polarizer output.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/EB02553,
http://linkedlifedata.com/resource/pubmed/grant/ES14005,
http://linkedlifedata.com/resource/pubmed/grant/HL67784,
http://linkedlifedata.com/resource/pubmed/grant/HL78285,
http://linkedlifedata.com/resource/pubmed/grant/HL82013,
http://linkedlifedata.com/resource/pubmed/grant/HL87550,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB002553-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB002553-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB002553-02S1,
http://linkedlifedata.com/resource/pubmed/grant/R01 EB002553-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL073632-01,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL073632-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL073632-03,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL073632-04,
http://linkedlifedata.com/resource/pubmed/grant/R01 HL73632,
http://linkedlifedata.com/resource/pubmed/grant/R21 RR014297-01A18280,
http://linkedlifedata.com/resource/pubmed/grant/R21 RR014297-02,
http://linkedlifedata.com/resource/pubmed/grant/R41 ES014005-01,
http://linkedlifedata.com/resource/pubmed/grant/R41 HL078285-01,
http://linkedlifedata.com/resource/pubmed/grant/R41 HL082013-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R41 RR020200-01,
http://linkedlifedata.com/resource/pubmed/grant/R42 ES014005-02,
http://linkedlifedata.com/resource/pubmed/grant/R42 HL078285-02,
http://linkedlifedata.com/resource/pubmed/grant/R42 HL078285-03,
http://linkedlifedata.com/resource/pubmed/grant/R43 HL087550-01,
http://linkedlifedata.com/resource/pubmed/grant/RR14297,
http://linkedlifedata.com/resource/pubmed/grant/RR20200
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-10601148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-10867696,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-10975884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-11754449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-12960548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-14164257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-14648564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-15065239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-15844148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-15981527,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-17101964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-17110518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-3823444,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-7264006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17890035-9178229
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0720-048X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
64
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
335-44
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pubmed:dateRevised |
2011-6-8
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pubmed:meshHeading |
pubmed-meshheading:17890035-Administration, Inhalation,
pubmed-meshheading:17890035-Animals,
pubmed-meshheading:17890035-Contrast Media,
pubmed-meshheading:17890035-Equipment Design,
pubmed-meshheading:17890035-Humans,
pubmed-meshheading:17890035-Image Enhancement,
pubmed-meshheading:17890035-Lasers,
pubmed-meshheading:17890035-Lung,
pubmed-meshheading:17890035-Magnetic Resonance Imaging,
pubmed-meshheading:17890035-Oxygen,
pubmed-meshheading:17890035-Oxygen Consumption,
pubmed-meshheading:17890035-Partial Pressure,
pubmed-meshheading:17890035-Pulmonary Alveoli,
pubmed-meshheading:17890035-Pulmonary Diffusing Capacity,
pubmed-meshheading:17890035-Rubidium,
pubmed-meshheading:17890035-Safety,
pubmed-meshheading:17890035-Technology, Radiologic,
pubmed-meshheading:17890035-Ventilation-Perfusion Ratio,
pubmed-meshheading:17890035-Xenon Isotopes
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pubmed:year |
2007
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pubmed:articleTitle |
Hyperpolarized (129)Xe MRI: a viable functional lung imaging modality?
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pubmed:affiliation |
Center for Pulmonary Functional Imaging, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA. patz@bwh.harvard.edu
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pubmed:publicationType |
Journal Article
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