| pubmed-article:17889672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17889672 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:17889672 | lifeskim:mentions | umls-concept:C0890466 | lld:lifeskim |
| pubmed-article:17889672 | lifeskim:mentions | umls-concept:C1446409 | lld:lifeskim |
| pubmed-article:17889672 | lifeskim:mentions | umls-concept:C0015744 | lld:lifeskim |
| pubmed-article:17889672 | lifeskim:mentions | umls-concept:C2911691 | lld:lifeskim |
| pubmed-article:17889672 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:17889672 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:17889672 | pubmed:dateCreated | 2007-9-24 | lld:pubmed |
| pubmed-article:17889672 | pubmed:abstractText | The regulation of transporters by nutrient-responsive signaling pathways allows cells to tailor nutrient uptake to environmental conditions. We investigated the role of feedback generated by transporter regulation in the budding yeast phosphate-responsive signal transduction (PHO) pathway. Cells starved for phosphate activate feedback loops that regulate high- and low-affinity phosphate transport. We determined that positive feedback is generated by PHO pathway-dependent upregulation of Spl2, a negative regulator of low-affinity phosphate uptake. The interplay of positive and negative feedback loops leads to bistability in phosphate transporter usage--individual cells express predominantly either low- or high-affinity transporters, both of which can yield similar phosphate uptake capacity. Cells lacking the high-affinity transporter, and associated negative feedback, exhibit phenotypes that arise from hysteresis due to unopposed positive feedback. In wild-type cells, population heterogeneity generated by feedback loops may provide a strategy for anticipating changes in environmental phosphate levels. | lld:pubmed |
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| pubmed-article:17889672 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17889672 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17889672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17889672 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:17889672 | pubmed:issn | 1097-2765 | lld:pubmed |
| pubmed-article:17889672 | pubmed:author | pubmed-author:O'SheaErin... | lld:pubmed |
| pubmed-article:17889672 | pubmed:author | pubmed-author:WykoffDennis... | lld:pubmed |
| pubmed-article:17889672 | pubmed:author | pubmed-author:RaserJonathan... | lld:pubmed |
| pubmed-article:17889672 | pubmed:author | pubmed-author:RizviAbbas... | lld:pubmed |
| pubmed-article:17889672 | pubmed:author | pubmed-author:MargolinBrian... | lld:pubmed |
| pubmed-article:17889672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17889672 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:17889672 | pubmed:volume | 27 | lld:pubmed |
| pubmed-article:17889672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17889672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17889672 | pubmed:pagination | 1005-13 | lld:pubmed |
| pubmed-article:17889672 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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| pubmed-article:17889672 | pubmed:meshHeading | pubmed-meshheading:17889672... | lld:pubmed |
| pubmed-article:17889672 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17889672 | pubmed:articleTitle | Positive feedback regulates switching of phosphate transporters in S. cerevisiae. | lld:pubmed |
| pubmed-article:17889672 | pubmed:affiliation | Howard Hughes Medical Institute, FAS Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, MA 02138, USA. | lld:pubmed |
| pubmed-article:17889672 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17889672 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:17889672 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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