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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-9-24
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pubmed:abstractText |
The regulation of transporters by nutrient-responsive signaling pathways allows cells to tailor nutrient uptake to environmental conditions. We investigated the role of feedback generated by transporter regulation in the budding yeast phosphate-responsive signal transduction (PHO) pathway. Cells starved for phosphate activate feedback loops that regulate high- and low-affinity phosphate transport. We determined that positive feedback is generated by PHO pathway-dependent upregulation of Spl2, a negative regulator of low-affinity phosphate uptake. The interplay of positive and negative feedback loops leads to bistability in phosphate transporter usage--individual cells express predominantly either low- or high-affinity transporters, both of which can yield similar phosphate uptake capacity. Cells lacking the high-affinity transporter, and associated negative feedback, exhibit phenotypes that arise from hysteresis due to unopposed positive feedback. In wild-type cells, population heterogeneity generated by feedback loops may provide a strategy for anticipating changes in environmental phosphate levels.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-10206902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-10320381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-10655492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-11102525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-11489853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-11675494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-11779791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-11891111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-12051835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-12095998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-12730459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-12748282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-12821119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-14624238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-14973486,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-14976557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-15014083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-15187181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-15757681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-15889097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-15892653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-15972809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-16123265,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-16239477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-2038328,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-7939631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-8108735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-8539622,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-8918192,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-9475719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-9516981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-9544531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-9566882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17889672-9693717
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1005-13
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:17889672-Biological Transport,
pubmed-meshheading:17889672-Cyclin-Dependent Kinase Inhibitor Proteins,
pubmed-meshheading:17889672-Down-Regulation,
pubmed-meshheading:17889672-Feedback, Physiological,
pubmed-meshheading:17889672-Mutation,
pubmed-meshheading:17889672-Phenotype,
pubmed-meshheading:17889672-Phosphate Transport Proteins,
pubmed-meshheading:17889672-Proton-Phosphate Symporters,
pubmed-meshheading:17889672-Saccharomyces cerevisiae,
pubmed-meshheading:17889672-Saccharomyces cerevisiae Proteins
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pubmed:year |
2007
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pubmed:articleTitle |
Positive feedback regulates switching of phosphate transporters in S. cerevisiae.
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pubmed:affiliation |
Howard Hughes Medical Institute, FAS Center for Systems Biology, Harvard University, 7 Divinity Avenue, Bauer 307, Cambridge, MA 02138, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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