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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-9-24
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pubmed:abstractText |
A major cause of cell death caused by genotoxic stress is thought to be due to the depletion of NAD(+) from the nucleus and the cytoplasm. Here we show that NAD(+) levels in mitochondria remain at physiological levels following genotoxic stress and can maintain cell viability even when nuclear and cytoplasmic pools of NAD(+) are depleted. Rodents fasted for 48 hr show increased levels of the NAD(+) biosynthetic enzyme Nampt and a concomitant increase in mitochondrial NAD(+). Increased Nampt provides protection against cell death and requires an intact mitochondrial NAD(+) salvage pathway as well as the mitochondrial NAD(+)-dependent deacetylases SIRT3 and SIRT4. We discuss the relevance of these findings to understanding how nutrition modulates physiology and to the evolution of apoptosis.
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pubmed:grant |
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916-010003,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916-020003,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916-030003,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916-040003,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916-04S10003,
http://linkedlifedata.com/resource/pubmed/grant/P01 AG027916-04S20003,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG019719-06A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG019719-07,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG028730-01A1,
http://linkedlifedata.com/resource/pubmed/grant/R01 AG028730-02,
http://linkedlifedata.com/resource/pubmed/grant/R01 DK 073466,
http://linkedlifedata.com/resource/pubmed/grant/R01AG028730,
http://linkedlifedata.com/resource/pubmed/grant/R01GM068072
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Methanesulfonate,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mutagens,
http://linkedlifedata.com/resource/pubmed/chemical/NAD,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinamide...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/SIRT3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sirtuin 3,
http://linkedlifedata.com/resource/pubmed/chemical/Sirtuins,
http://linkedlifedata.com/resource/pubmed/chemical/nicotinamide...,
http://linkedlifedata.com/resource/pubmed/chemical/nicotinamide...,
http://linkedlifedata.com/resource/pubmed/chemical/nicotinamide...
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0092-8674
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pubmed:author |
pubmed-author:BaurJoseph AJA,
pubmed-author:BohrVilhelm AVA,
pubmed-author:CarmonaJuan JJJ,
pubmed-author:LammingDudley WDW,
pubmed-author:MatsuiTakashiT,
pubmed-author:PerezEvelynE,
pubmed-author:RosenzweigAnthonyA,
pubmed-author:SauveAnthony AAA,
pubmed-author:SinclairDavid ADA,
pubmed-author:Souza-PintoNadja CNC,
pubmed-author:YangHongyingH,
pubmed-author:YangTianleT,
pubmed-author:de CaboRafaelR
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1095-107
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pubmed:dateRevised |
2011-2-14
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pubmed:meshHeading |
pubmed-meshheading:17889652-Animals,
pubmed-meshheading:17889652-Apoptosis,
pubmed-meshheading:17889652-Cell Hypoxia,
pubmed-meshheading:17889652-Cell Line,
pubmed-meshheading:17889652-Cell Nucleus,
pubmed-meshheading:17889652-Cell Survival,
pubmed-meshheading:17889652-Cells, Cultured,
pubmed-meshheading:17889652-Cytokines,
pubmed-meshheading:17889652-Cytoplasm,
pubmed-meshheading:17889652-Fasting,
pubmed-meshheading:17889652-Food Deprivation,
pubmed-meshheading:17889652-Humans,
pubmed-meshheading:17889652-Methyl Methanesulfonate,
pubmed-meshheading:17889652-Mice,
pubmed-meshheading:17889652-Mitochondria,
pubmed-meshheading:17889652-Mitochondrial Proteins,
pubmed-meshheading:17889652-Mutagens,
pubmed-meshheading:17889652-NAD,
pubmed-meshheading:17889652-Nicotinamide Phosphoribosyltransferase,
pubmed-meshheading:17889652-RNA, Small Interfering,
pubmed-meshheading:17889652-RNA Interference,
pubmed-meshheading:17889652-Rats,
pubmed-meshheading:17889652-Sirtuin 3,
pubmed-meshheading:17889652-Sirtuins,
pubmed-meshheading:17889652-Spectrometry, Mass, Matrix-Assisted Laser...,
pubmed-meshheading:17889652-Transfection,
pubmed-meshheading:17889652-Up-Regulation
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pubmed:year |
2007
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pubmed:articleTitle |
Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival.
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pubmed:affiliation |
Department of Pathology, Paul F. Glenn Laboratories, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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