| pubmed-article:17889545 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C0010453 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C0225369 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:17889545 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:17889545 | pubmed:issue | 24 | lld:pubmed |
| pubmed-article:17889545 | pubmed:dateCreated | 2007-10-22 | lld:pubmed |
| pubmed-article:17889545 | pubmed:abstractText | 5-Arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones (7,8) were synthesized and evaluated for their antidegenerative activity on human chondrocyte cultures stimulated by IL-1beta. This in vitro model has proven to be a useful experimental model to reproduce the mechanisms involved in arthritic diseases. The cell viability, the amount of GAGs, the production of NO and PGE(2) and the inhibition of MMP-3 were measured. Several thiazolidinones 7 and 8 exhibited the ability to block the production or action of the degenerative factors induced by IL-1beta. | lld:pubmed |
| pubmed-article:17889545 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17889545 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17889545 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17889545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17889545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17889545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17889545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17889545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17889545 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17889545 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17889545 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:MaccariRosann... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:OttanàRosaria... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:VigoritaMaria... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:CardileVenera... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:PanicoAnna... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:GarufiFlorian... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:RonsisvalleSi... | lld:pubmed |
| pubmed-article:17889545 | pubmed:author | pubmed-author:CiurleoRosell... | lld:pubmed |
| pubmed-article:17889545 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17889545 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17889545 | pubmed:volume | 15 | lld:pubmed |
| pubmed-article:17889545 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17889545 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17889545 | pubmed:pagination | 7618-25 | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
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| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
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| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:meshHeading | pubmed-meshheading:17889545... | lld:pubmed |
| pubmed-article:17889545 | pubmed:year | 2007 | lld:pubmed |
| pubmed-article:17889545 | pubmed:articleTitle | Synthesis and in vitro evaluation of 5-arylidene-3-hydroxyalkyl-2-phenylimino-4-thiazolidinones with antidegenerative activity on human chondrocyte cultures. | lld:pubmed |
| pubmed-article:17889545 | pubmed:affiliation | Dipartimento Farmaco-chimico, Università di Messina, Polo Universitario dell'Annunziata, 98168 Messina, Italy. | lld:pubmed |
| pubmed-article:17889545 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17889545 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:17889545 | lld:chembl |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17889545 | lld:pubmed |
